Core differences and pricing
Simple Online Pharmacy focuses on medication delivery with basic prescriber oversight, while Second Nature combines medication with comprehensive lifestyle support and daily access to registered nutritionists.
While Simple Online Pharmacy generally offers lower upfront costs for the medication itself, Second Nature’s approach includes both the medication and a complete support programme designed to create lasting habit change.
Important 2025 update: Simple Online Pharmacy has temporarily paused new Mounjaro prescriptions and limited existing patients to 4-week supplies due to ongoing shortages following the September 2025 price increases.
In contrast, Second Nature continues to guarantee medication supply for all members thanks to our exclusive supply agreements.
While Simple Online Pharmacy appears less expensive initially, research shows that comprehensive support significantly improves long-term outcomes, potentially making Second Nature more cost-effective when considering sustained results.
Support comparison
The level of support you receive is the most significant difference between these providers and directly impacts your chances of maintaining weight loss after medication.
Comprehensive support comparison
| Support Feature |
Simple Online Pharmacy |
Second Nature |
| Clinical oversight |
Online doctor assessment |
Online doctor assessment |
| Guaranteed medication supply |
❌ Currently paused for new patients |
✅ Guaranteed through exclusive partnerships |
| Dietitian/nutritionist access |
❌ Not provided |
✅ Daily access (Mon-Fri) |
| Psychology-based support |
❌ Not provided |
✅ Comprehensive programme |
| Peer group support |
❌ Not provided |
✅ Dedicated group |
| App with tracking tools |
❌ Basic medication reminders only |
✅ Award-winning app with meal/weight tracking |
| Educational resources |
✅ Basic medication guides |
✅ Daily articles and audio content |
| Recipe library |
❌ Not provided |
✅ 300+ balanced recipes |
| Habit formation guidance |
❌ Not provided |
✅ Structured psychology-based programme |
| Post-medication planning |
❌ Not addressed |
✅ Ongoing support from our health coaches |
Simple Online Pharmacy states medications should be used “alongside diet and exercise,” but these elements are entirely self-managed with no structured guidance or accountability.
Second Nature’s approach focuses on building sustainable habits that support weight maintenance even after medication, addressing the psychological and behavioural factors that drive weight regain.
This difference becomes particularly important when considering what happens after you stop taking the medication, as discussed in the next section.
2025 medication supply challenges
⚠️ Important Notice: Second Nature Guarantees Mounjaro Supply
While Simple Online Pharmacy has paused accepting new Mounjaro patients, Second Nature continues to guarantee medication supply for all members through our exclusive pharmaceutical partnerships. No waiting lists or supply interruptions for our members.
The UK weight loss medication market has experienced significant disruption in 2025, affecting availability, pricing, and access across most providers.
Recent price increases have seen Mounjaro costs rise significantly since mid-2025, creating supply constraints that have forced many online pharmacies to implement waiting lists or pause new prescriptions altogether.
Simple Online Pharmacy has been forced to implement a waiting list for new Mounjaro patients, with no guaranteed timeframe for resuming full service, and has limited existing patients to 4-week supplies.
Second Nature’s partnerships and clinical credibility ensure we can continue providing uninterrupted medication access for both new and existing members; a critical advantage during these industry-wide shortages.
For anyone considering starting weight loss medication in late 2025, reliable medication access combined with comprehensive support provides the optimal foundation for success, especially when planning for long-term results.
NHS partnership and clinical evidence
Second Nature has been trusted by the NHS since 2017 to deliver weight management and type 2 diabetes programmes, with extensive clinical validation.
Provider credibility comparison
| Credibility Factor |
Simple Online Pharmacy |
Second Nature |
| NHS partnership |
❌ No NHS programmes |
✅ Used by NHS since 2017 |
| NICE approval |
❌ No NICE approval |
✅ NICE-approved for NHS weight management |
| Clinical evidence |
❌ No published research |
✅ Multiple peer-reviewed publications |
| Regulatory status |
✅ CQC-registered pharmacy |
✅ CQC-registered provider, NHS partner |
| Healthcare professional team |
✅ Registered doctors |
✅ Doctors, dietitians, nutritionists, psychologists |
| Years in operation |
10+ years |
7+ years |
| Guaranteed medication supply |
❌ Currently unavailable |
✅ Secured through strategic partnerships |
The National Institute for Health and Care Excellence (NICE) recently announced that Wegovy would be available via digital weight management services provided by Second Nature and three other companies supporting the NHS.
This recognition reflects the high level of patient care and evidence-based approach that Second Nature provides.
Simple Online Pharmacy is a legitimate, CQC-registered pharmacy but doesn’t offer NHS-commissioned services or have the same level of clinical research validation.
Customer experience
Both providers maintain strong customer ratings, though with different strengths highlighted in reviews.
Customer satisfaction comparison
| Aspect |
Simple Online Pharmacy |
Second Nature |
| Trustpilot score (2025) |
4.6/5 from 21,000+ reviews |
4.8/5 from 7,600+ reviews |
| Most common positive feedback |
Fast delivery, straightforward process |
Supportive coaches, sustainable results |
| Most common negative feedback |
Limited support, medication supply issues |
Higher initial cost, app technical issues |
| Customer service hours |
Email only, 24-48 hour response |
Available 7 days a week; live chat or email |
| Response to 2025 supply issues |
Paused new Mounjaro patients |
Guaranteed supply for all members |
Recent Simple Online Pharmacy reviews highlight prompt delivery and clear instructions but also mention frustrations with medication supply issues and minimal human contact when problems arise.
Second Nature reviews frequently mention the value of coach support, psychology-based approach, and reliable medication access, with many customers reporting sustained results even after completing the programme.
This comprehensive approach is reflected in member testimonials. As one Second Nature participant shared:
“Having carried out lots of research, I opted to do my medicated weight loss program with Second Nature. Each day there is information to listen to or read (whichever is your preference) to educate you on food, eating right, being healthy … to retrain and learn how to make the right choices once a healthy weight is reached.
The support of my coach Monet has been so useful, in motivating me to eat enough protein, to exercise, to query my past and present food choices.
These support mechanisms, the medication itself, and the support of my group (sharing our experiences on the journey) are empowering me to know that this time my yo-yo dieting past is behind me and a healthier me is already emerging. Thank you Second Nature!”
This firsthand experience highlights how the combination of daily education, coach support, and group community creates a framework for sustainable change beyond medication alone.
Who should choose each option
Your personal circumstances and preferences will determine which provider is better suited to your needs.
Choose Simple Online Pharmacy if you:
- Prioritise lower upfront medication cost
- Have previous success with self-managed weight loss
- Already understand nutrition and exercise fundamentals
- Have strong self-motivation and accountability
- Don’t need or want regular professional guidance
- Are comfortable managing side effects independently
- Are willing to wait for medication availability to resume
Choose Second Nature if you:
- Need guaranteed Mounjaro access without supply interruptions
- Want comprehensive support alongside medication
- Value daily access to registered nutritionists
- Need help developing sustainable habits
- Have struggled with weight loss maintenance before
- Prefer structured guidance with accountability
- Want help managing medication side effects
- Seek peace of mind from NHS-validated programmes
- Plan to maintain weight loss after stopping medication
The right choice depends on whether you view medication as the complete solution or as a tool to help you build lasting habits.
Frequently asked questions
Is Simple Online Pharmacy cheaper than Second Nature?
While Simple Online Pharmacy has lower upfront costs for the medication itself, Second Nature includes daily access to registered nutritionists, an award-winning app, and a comprehensive habit-change programme alongside medication, potentially offering better long-term value through sustained results.
Can I get Mounjaro from Simple Online Pharmacy in late 2025?
As of October 2025, Simple Online Pharmacy has temporarily paused accepting new Mounjaro patients due to supply constraints following the September price increases. Existing patients are limited to 4-week supplies. There’s no confirmed date for resuming full service.
Does Second Nature guarantee Mounjaro supply?
Yes, unlike many providers facing supply challenges, Second Nature guarantees Mounjaro availability for all members through our strategic pharmaceutical partnerships. There are no waiting lists or supply interruptions for our members.
Does Second Nature have NHS approval?
Yes, Second Nature has been trusted by the NHS since 2017 and is one of only four digital providers recently approved by NICE to deliver weight management services with Wegovy through the NHS.
What happens when I stop medication with each provider?
With Simple Online Pharmacy, you’d be managing the transition independently. Research shows 67% of weight is typically regained without proper support.
Second Nature provides ongoing habit support to help you come off the medication slowly and maintain weight loss.
Can I switch between providers?
Yes, you can switch between providers at any time. If you’re currently with Simple Online Pharmacy and experiencing medication supply issues, Second Nature can help transfer your prescription while providing guaranteed medication access and additional support services.
Take home message
When choosing between Simple Online Pharmacy and Second Nature in 2025, the decision comes down to whether you want medication-only or comprehensive weight loss support alongside your medication.
Simple Online Pharmacy offers lower initial costs but provides minimal support beyond medication delivery and currently cannot guarantee Mounjaro access for new patients.
Second Nature combines guaranteed medication supply with daily access to registered nutritionists, a psychology-based habit change programme, and NHS-validated methods designed to help you maintain results long-term.
With 2025’s ongoing medication supply challenges, having both reliable medication access and trusted support becomes even more valuable, particularly if you’re planning for sustainable weight loss beyond the medication itself.
The best choice for you depends on your personal needs, but research consistently shows that comprehensive support alongside medication leads to better long-term weight management success.
Second Nature's Mounjaro and Wegovy programmes
Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes.
Why choose Second Nature over other medication providers, assuming you're eligible?
Because peace of mind matters.
We've had the privilege of working with the NHS for over eight years, helping people across the UK take meaningful steps toward a healthier, happier life.
Our programmes are designed to meet people where they are, whether that means support with weight loss through compassionate one-to-one health coaching, or access to the latest weight-loss medications (like Mounjaro and Wegovy) delivered alongside expert care from a multidisciplinary team of doctors, psychologists, dietitians, and personal trainers.
At the heart of everything we do is a simple belief: real, lasting change comes from building better habits, not relying on quick fixes. We're here to support that change every step of the way.
With over a decade of experience, thousands of lives changed, and a long-standing record of delivering programmes used by the NHS, we believe we're the UK's most trusted weight-loss programme.
We hope to offer you something invaluable: peace of mind, and the support you need to take that first step.
