NHS vs private access: 2025 guidelines
Access Route |
BMI required |
Additional requirements |
Typical wait |
Regulatory framework |
NHS |
≥40 (or ≥37.5 certain ethnicities) |
Must have four of five specific comorbidities: type 2 diabetes, hypertension, cardiovascular disease, sleep apnoea, dyslipidaemia |
12-18 months |
NICE Technology Appraisal TA10264 & NHS England 2025 Cohort Guidance5 |
Private |
≥30 (or ≥27 with health conditions) |
Online health assessment compliant with GMC remote prescribing guidelines |
1-2 weeks |
MHRA Human Medicines Regulations 2012 (as amended 2024) |
The NHS England interim commissioning guidance for tirzepatide (Mounjaro) acknowledges that implementation follows a phased approach, with initial criteria focused on patients at highest clinical risk5.
This tiered implementation means that many individuals who could potentially benefit from weight loss medication may not currently meet NHS eligibility thresholds.
Where can I get a private prescription of Mounjaro?
You have three primary options for accessing Mounjaro privately in the UK, each with different levels of support and oversight:
1. Comprehensive programmes like Second Nature that combine medication with registered dietitian support and habit-change coaching. These follow the NICE-recommended multidisciplinary support model4.
2. Online pharmacies that provide the medication with basic medical screening and limited ongoing support, regulated under MHRA’s Human Medicines Regulations.
3. Private GP clinics offering face-to-face consultations with traditional medical monitoring, following GMC guidelines for prescribing and medicine management.
Eligibility requirements, based on NICE guidance4 and Summary of Product Characteristics:
- BMI of 30 or higher (or 27+ with weight-related health conditions)
- Aged 18-75 years
- No contraindications as outlined in the medication’s label
- Commitment to lifestyle changes alongside medication
Medical contraindications (per Mounjaro SPC):
- Under 18 or over 75 years old
- Pregnant, breastfeeding, or trying to conceive
- Personal or family history of medullary thyroid carcinoma or MEN2
- History of pancreatitis or severe gastrointestinal disorders
- Severe renal impairment (eGFR <30 ml/min/1.73m²)
The prescription process typically involves completing an online health questionnaire that’s reviewed by a GMC-registered prescriber, followed by an ID verification check to prevent fraud, as required by MHRA regulations.
How much does a private UK Mounjaro prescription cost?
Second Nature programme pricing (2025):
- New prices to be confirmed in October 2025 at the latest
This includes medication, delivery, medical oversight, and support from registered dietitians in line with NICE’s recommendations for ‘wraparound’ support4.
Medication-only providers typically charge:
- Prices have increased since September 2025 and are variable, but broadly the cost of the medication is between £200-£380 per month depending on the dose and the provider
- Some providers now offer coaching and other elements of support as an additional fee, rather than having a fixed cost of medication + support
According to data published in JMIR Formative Research by Richards et al. (2025), patients receiving comprehensive support alongside medication achieved 19.1% average weight loss6.
This average weight loss is ~3-6% more than achieved in the clinical trials on Wegovy where patients had minimal support alongside the medication, suggesting that Second Nature’s increased support help to optimise weight loss results on Wegovy.
Treatment duration considerations:
NICE guidance doesn’t specify a maximum treatment duration for GLP-1 medications4, but clinical practice typically involves:
- Initial 3-6 month assessment period
- Continuation if achieving ≥5% weight loss at 6 months
- Total treatment duration of 12-24 months for most patients
The total investment ranges from approximately £2,750-£7,200, depending on provider, duration, and level of support.
Is there a waiting list for Mounjaro prescriptions?
Current private provider situation (September 2025):
Based on current market conditions, there’s no significant waiting list for Mounjaro with most regulated private providers. Once your health assessment is approved by a qualified prescriber:
- Initial consultation: 1-5 business days
- Prescription processing: 2-3 business days
- Delivery: 1-5 business days
- Total timeline: Typically 7-14 days from application to receipt
NHS pathway (based on NHS England guidance5):
- Initial GP consultation and referral: 2-4 weeks
- Specialist weight management service assessment: 3-6 months
- Mandatory participation in tier 3 weight management programme: 6 months
- Treatment initiation if approved: 3-6 months
- Total timeline: 12-18 months average
NHS England data suggests that a limited number of NHS prescriptions for tirzepatide have been issued to date, primarily due to the restrictive eligibility criteria in the first phase of implementation5.
The Department of Health and Social Care has announced plans to expand specialist weight management services, but implementation timelines extend to 2027 with a phased cohort approach targeting highest-risk patients first5.
Supply constraints and availability
Current UK supply status (September 2025):
The Medicines and Healthcare products Regulatory Agency (MHRA) maintains a database of medicine shortages, which currently shows stable supply for all Mounjaro doses in the UK market. Most established providers have reliable access through:
- Direct relationships with multiple pharmaceutical wholesalers
- Allocation agreements with manufacturers
- Partnership with multiple pharmacy networks
Historical context:
In early 2024, the MHRA reported temporary supply constraints affecting higher doses (7.5 mg+), which were resolved by May 2024 following manufacturing capacity expansions.
Factors affecting future availability:
Several factors may impact future supply:
- Expanding NHS pilot programmes for weight management medications
- Manufacturing capacity constraints at global production facilities
- Regulatory changes to prescribing guidelines
When evaluating providers, enquire about:
- Their contingency plans for potential shortages
- Policies regarding dose substitutions if needed
- Communication protocols for supply disruptions
Consistent access is important as interruptions in treatment can affect progress and potentially increase side effects if stopping and restarting.
Choosing the right provider
When selecting a provider for Mounjaro, the evidence points to significant differences in both immediate results and long-term success based on the approach taken.
The medical evidence for comprehensive approaches:
Richards et al.’s 2025 study on Second Nature’s programme published in JMIR Formative Research demonstrated several key findings6:
- Participants receiving comprehensive support achieved 19.1% average weight loss vs 13-16% with medication alone
- 77.7% of supported participants achieved ≥10% weight loss
Provider comparison framework:
Support element |
Comprehensive programmes |
Medication-only providers |
Clinical importance |
Medical screening |
GMC-registered prescribers with obesity medicine experience |
Basic eligibility checks |
Safety and appropriate patient selection |
Nutritional support |
Registered dietitians available 5 days/week |
Basic guidance materials |
Essential for muscle preservation during weight loss |
Psychological support |
Behavioural change specialists and peer groups |
Minimal or none |
Critical for addressing emotional eating patterns |
Side effect management |
Proactive protocols and coaching support |
Reactive guidance if requested |
Improves medication adherence and outcomes |
Post-medication planning |
Structured transition protocols |
Limited or none |
Prevents weight regain after stopping |
Safety monitoring |
Regular check-ins and progress tracking |
Basic medical questionnaires |
Required by GMC remote prescribing guidance |
Regulatory considerations:
The General Medical Council’s guidelines on remote prescribing (updated 2024) specify that providers must ensure:
- Appropriate clinical assessment before prescribing
- Adequate monitoring arrangements
- Continuity of care
- Secure handling of patient information
When evaluating providers, verify they meet these regulatory requirements and have clear protocols for managing potential complications.
Mounjaro vs Wegovy comparison
Both medications have UK approval for weight loss, with Mounjaro (tirzepatide) showing slightly better results in clinical trials.
Head-to-head comparison based on clinical trials:
Metric |
Mounjaro (Tirzepatide) |
Wegovy (Semaglutide) |
Clinical Significance |
Average weight loss |
15-22.5%3 |
12-16% |
Mounjaro shows ~4-6% greater average weight reduction |
≥15% weight loss |
55-63% of patients |
30-40% of patients |
Substantially more patients achieve significant weight loss with Mounjaro |
Mechanism of action |
Dual GLP-1 and GIP agonist |
GLP-1 agonist only |
Additional GIP activation may explain enhanced efficacy |
Dosing schedule |
Weekly injection |
Weekly injection |
Similar patient experience |
NHS availability |
Extremely limited |
Very limited |
Both have similar access challenges on NHS |
Side effect profile |
Primarily gastrointestinal |
Primarily gastrointestinal |
Similar safety profiles with slightly higher GI events with Mounjaro |
Clinical considerations:
Factors that might influence medication choice include:
- Previous response to similar medications
- Other conditions like diabetes (both approved for T2D)
- Individual tolerance of side effects
- Cost considerations (similar for most providers)
Both medications work through similar biological pathways, but Mounjaro’s additional GIP action appears to enhance weight loss effects.
Individual response varies, and some patients may respond better to one medication than the other regardless of average trial results.
NHS access criteria
Current NHS England criteria (September 2025):
Based on NICE Technology Appraisal TA1026 and NHS England’s 2025 Cohort Guidance, NHS prescribing of tirzepatide is currently restricted to patients who meet all of the following criteria4,5:
- BMI of 40 kg/m² or above (or 37.5 kg/m² or above for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds)
- Must have four of these five weight-related comorbidities requiring medication:
- Type 2 diabetes
- Hypertension
- Cardiovascular disease
- Obstructive sleep apnoea
- Dyslipidaemia
- Mandatory completion of a 6-month tier 3 weight management service programme
- Provision of ongoing specialist support throughout treatment
Regional variations and cohort approach:
NHS England has implemented a phased cohort approach to tirzepatide access5:
- Year 1 (2025): Only the highest-risk patients (meeting criteria above)
- Year 2-3 (2026-2027): Planned expansion to additional patient cohorts
- Regional Integrated Care Board (ICB) implementation varies significantly
The NHS Long Term Plan includes provisions for expanding weight management services by 2027, but current capacity remains extremely limited with priority given to those meeting the strict Year 1 cohort criteria5.
Prescription renewal process
Private Mounjaro prescriptions require regular review and renewal in line with GMC and MHRA guidelines for controlled medication management.
Typical renewal process:
Timeframe |
Requirements |
Regulatory basis |
Monthly |
• Weight update
• Side effect monitoring
• Basic health questionnaire |
MHRA Human Medicines Regulations |
3-Monthly |
• Comprehensive health review
• Progress assessment
• Dose evaluation |
GMC prescribing guidance |
6-Monthly |
• Full medication review
• Risk-benefit reassessment
• Treatment continuation decision |
NICE guidance |
According to NICE guidance, treatment should be continued only if the patient has lost at least 5% of their initial body weight at 6 months4.
Safety monitoring requirements:
Ongoing monitoring of specific parameters during treatment typically includes:
- Kidney function tests if history of renal impairment
- Pancreatic enzyme monitoring if abdominal pain occurs
- Blood pressure monitoring for those with hypertension
- Blood glucose monitoring for patients with diabetes
The renewal process differs between providers:
- Comprehensive programmes typically include integrated monitoring
- Medication-only services may require separate arrangements for tests
- All should comply with GMC remote prescribing standards
Frequently asked questions
How quickly can I get Mounjaro in the UK if I go private?
Most private providers can complete the assessment, prescribing, and delivery process within 7-14 days if you meet eligibility criteria. The timeline includes online assessment (1-2 days), prescriber review (1-3 days), and medication delivery (2-5 days).
Do I need a GP referral to get Mounjaro privately in the UK?
No, you don’t need a GP referral for private Mounjaro prescriptions. However, GMC guidelines recommend that private prescribers inform your NHS GP with your consent. This ensures your complete medical history is considered and prevents potential medication interactions.
What happens at a private Mounjaro consultation in the UK?
Private consultations typically involve:
- Comprehensive health questionnaire covering medical history
- Review of current medications and previous weight loss attempts
- Discussion of treatment expectations and potential side effects
- Explanation of monitoring requirements and follow-up process
- Identity verification to comply with MHRA regulations
Can I switch between Mounjaro and Wegovy?
Yes, switching between these medications is medically possible and sometimes recommended if you’re not responding well to one treatment.
Most specialists advise a brief washout period of 7 days when transitioning between GLP-1 medications. Your prescriber should assess your individual situation and adjust dosing appropriately.
How long can I stay on Mounjaro?
NICE guidance does not specify a maximum duration for GLP-1 medication treatment4. Most clinicians prescribe for 12-24 months, with regular reviews every 6 months to assess ongoing benefit. Long-term safety data now extends to 3 years with no new safety concerns identified.
Will the NHS eventually cover Mounjaro more broadly?
NHS England has announced plans to expand access to weight management medications through a phased cohort approach by 20275.
However, budget constraints and capacity limitations mean private prescribing will likely remain the primary access route for most eligible patients in the near future.
What are the eligibility requirements for Mounjaro in the UK?
For private prescriptions, eligibility typically includes a BMI of 30 or higher (or 27+ with weight-related health conditions), being aged 18-75 years, having no contraindications as outlined in the medication’s Summary of Product Characteristics, and a commitment to lifestyle changes alongside medication.
What side effects should I expect with Mounjaro?
The most common side effects are gastrointestinal, including nausea, constipation, and diarrhoea. These typically improve within 4-8 weeks as your body adjusts to the medication.
Comprehensive support programmes provide strategies to manage these side effects effectively, which significantly improves the treatment experience.
Take home message
Private Mounjaro prescriptions are readily available in the UK, with most eligible patients able to start treatment within 1-2 weeks of applying through registered providers.
While NHS access remains extremely limited due to strict NICE criteria and the phased cohort approach, private options provide effective pathways for weight management support that align with regulatory requirements.
The evidence strongly suggests that comprehensive programmes combining medication with professional support yield significantly better outcomes than medication alone, both during treatment and after stopping.
When choosing a provider, consider not just the monthly cost but the level of support provided, as this substantially impacts both immediate results and long-term success rates.
Most importantly, view Mounjaro as a tool that works best when combined with sustainable lifestyle changes rather than as a standalone solution, an approach that aligns with both NICE guidance and clinical best practice.
Second Nature's Mounjaro and Wegovy programmes
Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes.
Why choose Second Nature over other medication providers, assuming you're eligible?
Because peace of mind matters.
We've had the privilege of working with the NHS for over eight years, helping people across the UK take meaningful steps toward a healthier, happier life.
Our programmes are designed to meet people where they are, whether that means support with weight loss through compassionate one-to-one health coaching, or access to the latest weight-loss medications (like Mounjaro and Wegovy) delivered alongside expert care from a multidisciplinary team of doctors, psychologists, dietitians, and personal trainers.
At the heart of everything we do is a simple belief: real, lasting change comes from building better habits, not relying on quick fixes. We're here to support that change every step of the way.
With over a decade of experience, thousands of lives changed, and a long-standing record of delivering programmes used by the NHS, we believe we're the UK's most trusted weight-loss programme.
We hope to offer you something invaluable: peace of mind, and the support you need to take that first step.
References
1. Institute for Global Change. (2025). Anti-obesity medications: Faster, broader access can drive health and wealth in the UK
2. The King’s Fund. (2025). GLP-1 drugs: The NHS should roll them out at scale
3. Jastreboff, A.M., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205-216.
4. National Institute for Health and Care Excellence. (2024). Tirzepatide for managing overweight and obesity [TA1026]
5. NHS England. (2025). Weight Management Medications: Cohort Guidance 2025-2027
6. Richards, R., et al. (2025). A Remotely Delivered, Semaglutide-Supported Specialist Weight Management Program: 12-Month Outcomes from a Retrospective Service Evaluation. JMIR Formative Research, 9, e72577.
7. Wilding, J.P., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine, 384(11), 989-1002.