Jump to: At-a-glance comparison | Clinical evidence and results | Support models compared | Medication management | Cost comparison | Who should choose each option | Frequently asked questions | Take home message
Both Second Nature and Boots offer Mounjaro and Wegovy weight loss injections, with the key difference being Second Nature’s established clinical support system versus Boots’ newer behavioural support approach.
UK research shows that when these medications are combined with proper support, users achieve significantly better results; our JMIR study demonstrated an average weight loss of 19.1% at 12 months on Wegovy with comprehensive support.
This average weight loss is 3-6% more than participants on Wegovy achieved in clinical trials.
This guide discusses medication availability, rising prices, and maintaining weight loss after stopping treatment to help you make an informed decision about your ongoing weight loss treatment.
At-a-glance comparison: Second Nature vs Boots
| Feature |
Second Nature |
Boots Online Doctor |
| Experience with weight loss |
NHS-commissioned since 2017, over 250,000 patients supported |
Recently resumed weight loss services with expanded behavioural support |
| Clinical evidence |
BMJ and JMIR published studies showing significant weight loss after 12 months, with or without medication |
Limited published evidence for their support programme |
| Professional support |
Registered dietitians and nutritionists (5 days/week) |
Wellness coaches and nutritionists through Online Doctor Coach app |
| Group support |
Peer support groups with others on similar journey |
No peer group support reported |
| Medication pricing (Mounjaro) |
New pricing confirmed in October 2025 |
£144.99 (2.5mg) to £289.99 (15mg) per pen (support costs additional) |
| Medication pricing (Wegovy) |
£149-£249 monthly (all-inclusive with medication and £50 off the first month) |
£95 (0.25mg) to £209.99 (2.4mg) per pen (support costs additional) |
| Supply availability |
Established supply chain with ongoing availability |
Recently resumed service with noted potential supply delays |
| Trustpilot rating |
4.6/5 from over 7,500 reviews |
No verified Trustpilot account for medication service |
Clinical evidence and proven results
Evidence-based outcomes with proper support
Second Nature’s approach is backed by extensive clinical research, most recently in our 2025 JMIR Formative Research study examining 12-month outcomes with semaglutide combined with behavioural support. This study revealed:
- 19.1% average weight loss for participants who maintained an active subscription through 12 months
- 77.7% of participants achieved ≥10% weight loss at 12 months
- 61.5% achieved ≥15% weight loss at 12 months
- 69% reported no side effects by month 12 with proper support and guidance
These results exceed typical outcomes seen in standard care and highlight the importance of comprehensive support alongside medication.
Meanwhile, Boots has recently expanded their weight loss services to include behavioural support through their Online Doctor Coach app.
While this represents a positive step, their approach lacks the published clinical evidence and established track record of Second Nature’s programme.
NHS validation and partnerships
As of September 2025, Second Nature continues to expand NHS partnerships for both medication and non-medication weight loss services, including new Tier 3 contracts.
Our effectiveness was highlighted in NHS-published data in the British Medical Journal, which demonstrated that Second Nature was more than twice as effective at supporting weight loss than 4 other providers in the National Diabetes Prevention Programme.
This evidence-based approach sets Second Nature apart from Boots, whose newly developed behavioural support programme hasn’t yet demonstrated comparable clinical outcomes.
Support models compared
Professional guidance
The support you receive significantly impacts your weight loss success and ability to maintain results after stopping medication:
Second Nature:
- UK-registered dietitians and nutritionists available 5 days per week
- Both group and private chat support included in programme cost
- Specific training in GLP-1 medication side effect management
- Support addressing psychological aspects of eating behaviours
Boots Online Doctor:
- Wellness coaches and nutritionists through their Coach app
- Recently developed support structure
- Basic guidance on diet and exercise
- Limited published data on coach qualifications and approach
- Newer service with less established protocols
Long-term habit formation
Our JMIR study demonstrated that sustainable habit formation makes a significant difference in maintaining weight loss:
Second Nature approach:
- Structured curriculum developed by psychologists and dietitians
- Focuses on building habits from day one of medication
- Addresses emotional and psychological aspects of eating
- Develops skills that support weight maintenance after medication
- Community support from peers facing similar challenges
Boots approach:
- Provides basic lifestyle advice through their wellness coaches
- Recently developed behavioural programme
- Less structured curriculum for habit development
- Unclear approach to post-medication transition
- No reported peer support community
Medication management and availability
Recent industry changes (September 2025)
As of September 1, 2025, Mounjaro prices have increased across all UK providers due to manufacturer pricing changes. This affects affordability and has shifted some users toward Wegovy as a potentially more cost-effective option.
While Boots has resumed weight loss prescriptions for both Mounjaro and Wegovy as of September 2025, their website notes that “due to ongoing shortages, some users may experience delays or may have to switch doses temporarily.”
Second Nature maintains reliable medication supply through established relationships with pharmacy partners, minimising disruption to your weight loss journey.
Medication transition support
Patients often need the most support during medication transitions:
- When starting medication and managing initial side effects
- When adjusting dosages as treatment progresses
- When preparing to reduce or stop medication
Second Nature’s approach includes specific protocols for each transition phase, developed through years of experience with over 250,000 patients. Boots’ newer service has less established transition support.
Cost and value analysis
Comprehensive cost breakdown
Second Nature:
- £149-£249 monthly for Wegovy (all-inclusive with £50 off first month)
- Mounjaro prices to be confirmed in October
- Includes medication, delivery, coach support, and app access
- No hidden costs or additional fees
Boots Online Doctor:
- £95 (0.25mg) to £209.99 (2.4mg) per Wegovy pen
- £144.99 (2.5mg) to £289.99 (15mg) per Mounjaro pen (likely to increase)
- Additional costs for coach support and follow-up consultations
- Potential surcharges during supply shortages
Cost-effectiveness considerations
Our JMIR study found that remotely delivered GLP-1 medication with behavioural support could reduce costs to 30-40% of traditional NHS specialist weight management services while achieving comparable results.
When comparing providers, consider:
- Total monthly expenditure including all services
- Value of professional support for long-term results
- Cost of potential weight regain without proper support
- Reliability of supply and pricing stability
Who should choose each option?
Second Nature might be right for you if:
- You want comprehensive support alongside medication
- You’ve struggled with maintaining weight loss previously
- You value access to registered dietitians and nutritionists
- You benefit from community support and accountability
- You’re concerned about medication availability and consistency
- You want an evidence-based approach with published results
Boots might be right for you if:
- You primarily want access to medication with basic support
- You already have a good understanding of nutrition and habit change
- You prefer a minimal programme structure
- You have an established relationship with Boots for other healthcare
- You can manage potential supply delays and dose adjustments
- You’re comfortable with a newer, less proven support approach
Frequently asked questions
How much weight can I expect to lose with Mounjaro or Wegovy?
Our JMIR study showed that participants who completed 12 months of Second Nature’s supported programme lost an average of 19.1% of their starting weight.
Individual results vary, but 77.7% achieved at least 10% weight loss, and 61.5% achieved at least 15% weight loss at 12 months.
Which provider offers better availability of Mounjaro and Wegovy in September 2025?
While both Second Nature and Boots currently offer both medications, Boots notes on their website that “due to ongoing shortages, some users may experience delays or may have to switch doses temporarily.”
Second Nature maintains reliable supply through established pharmacy partnerships.
Does Boots offer the same level of support as Second Nature?
Boots has recently expanded their support through their Online Doctor Coach app with wellness coaches and nutritionists.
However, this differs from Second Nature’s programme which includes registered dietitians and nutritionists available 5 days per week, peer support groups, and a structured curriculum developed through years of NHS experience.
Are weight loss injections worth the cost compared to traditional dieting?
For many people with obesity, GLP-1 medications offer significant advantages over traditional dieting alone. They can reduce hunger and cravings, making it easier to adopt healthy habits.
However, they work best when combined with lifestyle changes and proper support, which is why choosing the right provider is crucial for long-term success.
Take home message
Weight loss medications like Mounjaro and Wegovy work best as tools to support lifestyle changes, not as standalone solutions. The support you receive alongside these medications significantly impacts both your initial results and long-term success.
Second Nature’s established programme combines GLP-1 medications with comprehensive behavioural support from registered dietitians and nutritionists, backed by published clinical evidence showing 19.1% average weight loss at 12 months.
Our NHS partnerships and experience supporting over 250,000 patients provide peace of mind during your weight loss journey.
While Boots has resumed their weight loss services with expanded behavioural support, their newer programme lacks the established track record and published evidence of Second Nature’s approach.
When choosing between providers, consider not just medication access but the quality of support that will help you maintain results for the long term.
The ultimate goal isn’t just short-term weight loss but developing sustainable habits that make losing weight feel second nature.
Second Nature's Mounjaro and Wegovy programmes
Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes.
Why choose Second Nature over other medication providers, assuming you're eligible?
Because peace of mind matters.
We've had the privilege of working with the NHS for over eight years, helping people across the UK take meaningful steps toward a healthier, happier life.
Our programmes are designed to meet people where they are, whether that means support with weight loss through compassionate one-to-one health coaching, or access to the latest weight-loss medications (like Mounjaro and Wegovy) delivered alongside expert care from a multidisciplinary team of doctors, psychologists, dietitians, and personal trainers.
At the heart of everything we do is a simple belief: real, lasting change comes from building better habits, not relying on quick fixes. We're here to support that change every step of the way.
With over a decade of experience, thousands of lives changed, and a long-standing record of delivering programmes used by the NHS, we believe we're the UK's most trusted weight-loss programme.
We hope to offer you something invaluable: peace of mind, and the support you need to take that first step.
