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The best weight-loss injections in 2024

Robbie Puddick
Written by

Robbie Puddick

Medically reviewed by

Fiona Moncrieff

4 min read
Last updated February 2024
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Jump to: 1. Tirzepatide | 2. Semaglutide | 3. Liraglutide | Should you use weight-loss injections? | Weight-loss injections aren’t a magic pill

Based on data from randomised controlled trials (the gold standard of medical research), the best weight loss injection that will be available in the UK in 2024 is tirzepatide (sold under the brand names Mounjaro and Zepbound).

Research has shown that tirzepatide supports an average weight loss of around 25% after one year.

However, tirzepatide isn’t yet available to purchase in the UK after being approved for weight loss and type 2 diabetes towards the end of 2023.

Other options available in the UK are semaglutide and liraglutide. Below, we’ve ranked the top three weight-loss injections that will be available in the UK in 2024.

  1. Tirzepatide (Mounjaro/Zepbound): Average weight loss of 25%
  2. Semaglutide (Wegovy): Average weight loss of 15-17%
  3. Liraglutide (Saxenda): Average weight loss of 5-7%

The best weight-loss injections 2024.

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1) Tirzepatide (Mounjaro/Zepbound)

The best weight-loss injection that will be available in the UK in 2024 is tirzepatide, sold under the brand names Mounjaro and Zepbound.

Tirzepatide has been approved in the UK for weight loss and type 2 diabetes. However, it’s not widely available for purchase or prescription, but this will likely change in the early months of 2024.

Research has shown that tirzepatide supports an average weight loss of around 25% after one year. This study also showed this weight loss was maintained after 20 months on the medication.

Tirzepatide is a weight-loss injection that you administer once a week and is manufactured by the pharmaceutical company Eli Lilly.

2) Semaglutide (Wegovy/Ozempic)

The second-best weight-loss injection available in the UK in 2024 will be semaglutide 2.4 mg (Wegovy).

Research has shown that semaglutide 2.4 mg (Wegovy) can support weight loss of around 16% after one year.

Wegovy has the same active ingredient as the type 2 diabetes medication Ozempic. Ozempic is available in doses up to 1 mg but is no longer available for weight loss in the UK.

Semaglutide is a weight-loss injection that you administer once weekly and is manufactured by the pharmaceutical company Novo Nordisk.

Second Nature launched a Wegovy-supported programme in 2023. To check your eligibility, click on the button below.

3) Liraglutide (Saxenda)

The third-best weight-loss injection available in the UK in 2024 is liraglutide (Saxenda). Research shows that liraglutide supports average weight loss of 5-7% after one year.

Saxenda is also prescribed for people living with type 2 diabetes, and while its impact on weight loss is modest, Saxenda has a very positive impact on blood sugar control.

One study showed that Saxenda supported over 56% of participants in lowering their blood sugars below the diagnostic threshold for type 2 diabetes.

Liraglutide is a weight-loss injection administered once daily and manufactured by the pharmaceutical company Novo Nordisk.

Should you use weight-loss injections?

Ideally, we’d be able to lose weight without medication through improved eating habits and a healthier lifestyle.

This is at the core of our mission: to eradicate type 2 diabetes and obesity and help 10 million people lose weight for good.

Second Nature has been working in the NHS since 2017, supporting individuals in losing weight and managing their type 2 diabetes.

Individuals on our programme lose an average of 7-10% of their body weight after 12 months, and we’ve been shown to be more than twice as effective as other weight-loss programmes in the UK.

Second Nature weight loss NHS

However, many people have spent their entire lives struggling with weight, and their barriers to weight loss are multi-faceted and complex.

In these situations, extra support may be needed, which is why weight-loss injections have been developed.

Much like antidepressants can provide individuals living with depression the ability to receive therapy to address the root causes of their condition, weight-loss injections like Mounjaro and Wegovy can provide a similar window of opportunity.

By reducing hunger and the desire to seek out food, individuals might feel a new sense of freedom to make healthier choices and address the underlying causes of their obesity.

Weight-loss injections aren’t a magic pill

The recent innovations in weight-loss injections are pretty remarkable and have caused quite a stir in the world of healthcare.

We’re in new territory where obesity and type 2 diabetes medications treat an underlying cause instead of merely treating the symptoms to support better management.

However, these drugs shouldn’t be seen as miracle cures; they’re not designed to be used for life.

They’ve been designed to be taken alongside lifestyle changes that will enable you to eventually come off the medications and maintain your lower weight for the long term.

GLP-1s like tirzepatide and semaglutide are safe and effective for most people in the short to medium term, but they’re not for everyone and shouldn’t be used as a fast track for success.

At Second Nature, we’re not against using medications to support people in making healthy changes and reducing their risk of chronic disease.

However, we don’t recommend using medications as a reason not to make healthy lifestyle changes. The causes of obesity and type 2 diabetes aren’t merely rooted in biology but also in psychology and sociology.

With these medications, you may lose weight and reduce blood sugar levels. But will you be happier? Will you be more fulfilled? Will you be content with your life and social relationships?

For that, you may need to consider a lifestyle change.

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