At-a-glance comparison: Second Nature vs Chemist-4-U
| Feature |
Second Nature |
Chemist-4-U |
| Core approach |
Medication + comprehensive habit change |
Medication-only with basic oversight |
| Professional support |
Registered dietitians and nutritionists (5 days/week) |
Basic medical screening only |
| Clinical evidence |
JMIR study showing 19.1% weight loss at 12 months |
No published programme-specific evidence |
| Mounjaro pricing |
Pricing confirmed in October |
From £148 per pen (basic oversight only and likely to increase soon) |
| Wegovy pricing |
£149-£249 monthly (all-inclusive with medication and £50 off the first month) |
From £99 per pen (basic oversight only) |
| Post-medication strategy |
Structured habit formation and ongoing support from a dietitian or nutritionist |
Not addressed |
| Side effect management |
Dedicated protocols and coaching support |
Basic information and FAQs |
| Peer support |
Groups with others on a similar journey |
None provided |
| Long-term outcomes |
Data showing sustained results |
No published long-term data |
Service models compared
Different approaches for support
The core difference between Second Nature and Chemist-4-U lies in their fundamental approach to weight management:
Second Nature integrates medication with evidence-based behavioural change, viewing weight loss injections as tools to support developing sustainable habits. Our programme was developed through years of NHS collaboration and is grounded in behavioural psychology.
Chemist-4-U operates a pharmacy-first model focused on medication access. After basic online screening, they provide prescription fulfilment and delivery with minimal ongoing support beyond FAQ resources.
The importance of support alongside medication
Research consistently shows that GLP-1 medications work best when combined with comprehensive lifestyle support:
- Our JMIR study revealed that participants with ongoing support achieved 19.1% weight loss at 12 months; 3-6% more than participants in clinical trials that have limited support
- 77.7% of supported participants achieved clinically significant weight loss (≥10%) versus 52.3% without comprehensive support
- After stopping medication, those without proper habit formation typically regain two-thirds of lost weight within a year
Long-term implications of each approach
The service model you choose significantly impacts your long-term outcomes:
Second Nature’s integrated approach:
- Builds sustainable habits from day one of medication
- Provides strategies for managing hunger when medication effects fluctuate
- Develops skills that support weight maintenance after medication
- Addresses psychological aspects of eating behaviours
Chemist-4-U’s pharmacy-first model:
- Focuses primarily on medication access and basic medical screening
- Places responsibility for lifestyle changes entirely on the individual
- Provides limited guidance on developing sustainable habits
- Offers no structured approach to post-medication transition
Medication management and pricing
True cost comparison
While Chemist-4-U’s per-pen pricing initially appears lower, calculating the full monthly cost reveals a different picture:
Second Nature:
- £149-£249 monthly for Wegovy + £50 off the first month (all-inclusive)
- Includes medication, delivery, professional support, and app access
- No hidden costs or additional fees
Chemist-4-U:
- From £148 per Mounjaro pen (approximately £592 monthly for 4 pens)
- From £99 per Wegovy pen (approximately £396 monthly for 4 pens)
- Basic medical screening included
- Additional costs for sharps bins and delivery
When considering the value of professional support and the potential costs of weight regain without proper habit formation, Second Nature’s all-inclusive approach often represents better long-term value.
Medication options and availability
Both services offer the leading GLP-1/GIP medications:
Second Nature provides:
- Mounjaro (tirzepatide)
- Wegovy (semaglutide)
- Established supply chain with ongoing availability
Chemist-4-U offers:
- Mounjaro (tirzepatide)
- Wegovy (semaglutide)
- Saxenda (liraglutide)
- Availability subject to market fluctuations
In the context of ongoing industry-wide supply challenges, Second Nature’s established pharmacy partnerships help ensure consistent medication access.
Professional support and guidance
Expert guidance differences
The level of professional support varies significantly between services:
Second Nature provides:
- UK-registered dietitians and nutritionists available 5 days per week
- Both group and private chat support
- Specific training in GLP-1 medication side effect management
- Support addressing psychological aspects of eating behaviours
- Regular check-ins and progress monitoring
Chemist-4-U offers:
- Online consultation for initial screening
- Basic FAQ resources on medication usage
- Limited ongoing professional guidance
- No specialised support for the psychological aspects of eating
Side effect management
GLP-1 medications commonly cause side effects, particularly in the early weeks. How these are managed significantly impacts your experience:
Second Nature’s approach:
- Proactive guidance on managing nausea, constipation, and fatigue
- Regular check-ins to monitor and address side effects
- Nutritional strategies to minimise digestive issues
- Our JMIR study showed 69% of participants reported no side effects by month 12 with proper support
Chemist-4-U’s approach:
- Basic information on potential side effects
- FAQ resources for common issues
- Reactive support if users report problems
- No proactive monitoring or specialised guidance
Long-term weight maintenance
Perhaps the most significant difference between services is their approach to long-term weight management:
Second Nature’s strategy:
- Structured curriculum for developing sustainable habits
- Specific protocols for medication transitions and eventual discontinuation
- Tools for managing hunger signals naturally
- Community support during challenging periods
Chemist-4-U’s approach:
- No structured plan for post-medication life
- Limited guidance on long-term weight maintenance
- No community or accountability systems
- Focus primarily on medication effects rather than sustainable change
Clinical evidence and results
Research-backed outcomes
Second Nature’s approach is supported by robust clinical evidence:
Our 2025 JMIR Formative Research study examined 12-month outcomes with semaglutide combined with behavioural support. Key findings included:
- 19.1% average weight loss for participants who maintained an active subscription
- 77.7% of participants achieved ≥10% weight loss at 12 months
- 61.5% achieved ≥15% weight loss at 12 months
- 69% reported no side effects by month 12 with proper support
Chemist-4-U references clinical trial data for the medications they supply, but has no published evidence on outcomes for their specific service model.
The science of habit formation and weight maintenance
Research shows that sustainable weight loss depends on addressing both biological and psychological factors:
- GLP-1 medications lower hunger and cravings but don’t change established eating patterns
- Research shows that those who address their underlying habits and behaviours are more likely to maintain weight loss in the long run
Second Nature’s programme incorporates this science into a structured approach to habit formation, while Chemist-4-U does not address these psychological components.
Who should choose each option?
Second Nature might be right for you if:
- You want comprehensive support alongside medication
- You’re concerned about maintaining weight loss after stopping medication
- You’ve struggled with dieting or weight cycling in the past
- You value professional guidance from registered dietitians
- You benefit from community support and accountability
- You’re looking for a long-term solution, not just temporary weight loss
- You want an evidence-based approach with published results
Chemist-4-U might be right for you if:
- You primarily want access to medication with minimal oversight
- You already have extensive knowledge of nutrition and behaviour change
- You have established self-management strategies for weight control
- You’re comfortable navigating side effects independently
- You prefer a purely transactional service without ongoing support
- You have external professional support (e.g., private dietitian)
- Cost is your primary consideration, regardless of long-term outcomes
Frequently asked questions
Is Chemist-4-U cheaper than Second Nature for weight loss injections?
While Chemist-4-U’s per-pen pricing appears lower initially, the monthly cost is often higher than Second Nature’s all-inclusive pricing.
More importantly, Second Nature includes professional support that may improve long-term outcomes and prevent costly weight regain.
How much weight can I lose with Mounjaro or Wegovy?
Our JMIR study showed that participants with comprehensive support lost an average of 19.1% of their starting weight at 12 months, compared to 11.9% for those without ongoing support.
Clinical trials of these medications typically show 15-17% weight loss on average, but results vary significantly based on individual factors and the support you receive.
Does Chemist-4-U offer support with weight loss injections?
Chemist-4-U provides basic medical screening and FAQ resources but does not offer ongoing professional support from registered dietitians or nutritionists, peer support groups, or a structured behavioural change programme like Second Nature does.
Which service is better for staying off weight loss medications?
Second Nature’s programme explicitly focuses on developing sustainable habits that support weight maintenance after stopping medication.
Our approach includes specific protocols for medication transitions and strategies for managing hunger naturally.
Chemist-4-U doesn’t appear to address post-medication life or weight maintenance strategies.
Can I get the same results with Chemist-4-U if I’m disciplined about diet and exercise?
While some highly motivated individuals might achieve similar results with minimal support, research consistently shows that comprehensive professional guidance significantly improves outcomes for most people.
Take home message
Weight loss medications like Mounjaro and Wegovy are effective tools for reducing hunger and cravings, supporting weight loss.
However, their long-term effectiveness largely depends on the support and habit changes that accompany them.
Second Nature’s programme combines these medications with comprehensive behavioural support from registered dietitians and nutritionists, backed by published clinical evidence showing an average weight loss of 19.1% at 12 months.
Our approach focuses not just on temporary weight reduction but on building sustainable habits that prevent weight regain after stopping medication.
Chemist-4-U offers a more straightforward medication-access model with basic oversight, which may appeal to those who already have strong self-management skills or external support systems.
However, their approach lacks the structured guidance, professional support, and evidence base that characterises Second Nature’s programme.
When choosing between services, consider not just the initial cost but the value of professional support for achieving lasting results.
The most effective weight loss strategy is one that develops habits you can maintain for life, making healthy weight management feel second nature.
Second Nature's Mounjaro and Wegovy programmes
Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes.
Why choose Second Nature over other medication providers, assuming you're eligible?
Because peace of mind matters.
We've had the privilege of working with the NHS for over eight years, helping people across the UK take meaningful steps toward a healthier, happier life.
Our programmes are designed to meet people where they are, whether that means support with weight loss through compassionate one-to-one health coaching, or access to the latest weight-loss medications (like Mounjaro and Wegovy) delivered alongside expert care from a multidisciplinary team of doctors, psychologists, dietitians, and personal trainers.
At the heart of everything we do is a simple belief: real, lasting change comes from building better habits, not relying on quick fixes. We're here to support that change every step of the way.
With over a decade of experience, thousands of lives changed, and a long-standing record of delivering programmes used by the NHS, we believe we're the UK's most trusted weight-loss programme.
We hope to offer you something invaluable: peace of mind, and the support you need to take that first step.
