Jump to: NHS Partnership & Clinical Evidence | Programme Comparison | Support & Coaching | Pricing & Value | Frequently Asked Questions | Take Home Message
When choosing between Zava and Second Nature for weight-loss medication support, the most significant difference is programme depth and ongoing support.
Research suggests that without proper habit change support, 68% of weight lost on GLP-1 medications returns within a year of stopping treatment.
Second Nature has been delivering NHS-commissioned weight-loss services since 2017, combining medication with daily access to registered dietitians and nutritionists.
Recent studies show Second Nature achieves more than double the weight loss outcomes of competitor programmes in NHS-linked services.
In contrast, Zava offers a streamlined medication service with doctor-reviewed prescriptions and essential written advice, but lacks the comprehensive behavioural support and daily professional guidance that research shows is crucial for long-term success.
Both services provide access to effective weight-loss medications, but Second Nature’s approach offers greater peace of mind for those seeking clinically-proven support for sustainable weight loss.
Second Nature also offers a weight-loss programme without medication starting from £33/month, which you can learn more about here.
Zava vs Second Nature: Key Programme Differences
| Feature |
Second Nature |
Zava |
| NHS Partnership |
NHS-commissioned since 2017, now providing Tier 3 weight management services across multiple UK regions |
No NHS partnerships; fully private service |
| Clinical Evidence |
Multiple peer-reviewed publications; most recent study showing weight loss of 19.1% after one year on Wegovy |
Relies on drug trial data only; no published research on their programme outcomes |
| Health Support |
UK-registered dietitians and nutritionists available 5 days a week with GLP-1 expertise + psychological resources for emotional eating |
GMC-registered doctor review of prescription; written advice on side effects and best practices |
| Medication Options |
Mounjaro, Wegovy |
Wegovy, Mounjaro, Saxenda, Orlistat |
| Digital Tools |
Custom-built app with food/mood tracking, 300+ recipes, habit tracking, and daily articles |
Limited digital tools; primarily written guidance |
| Monthly Cost |
£33/month for non-medication programme; Wegovy programme £149-£249 per month with £50 off the first month |
Wegovy: £179-£275; Mounjaro: £189-£209 |
| Post-medication Planning |
Comprehensive transition strategies and ongoing support |
Not specifically mentioned; self-initiated follow-up |
| User Satisfaction |
4.6/5 from 7,600+ Trustpilot reviews |
4.3/5 from 9,200+ Trustpilot reviews |
NHS partnership & clinical evidence
The foundation of any effective weight management programme lies in its clinical validation and evidence base. This becomes especially important when medication is involved.
Second Nature: NHS-trusted approach
At Second Nature, we’ve built our reputation on a strong foundation of clinical trust and evidence since our inception.
Since 2017, the NHS has commissioned us to deliver weight loss and type 2 diabetes programmes across the UK. As of April 2025, our NHS partnerships have expanded to include Tier 3 weight management services in new regions with updated eligibility criteria.
This partnership with the NHS reflects the confidence healthcare professionals place in our approach, which is grounded in behaviour change psychology and sustainable habit formation.
The effectiveness of our approach is supported by peer-reviewed research published in the British Medical Journal:
- Our members lose an average of 5.9kg at 12 weeks
- 62.5% achieved at least 5% weight loss by 3 months
- 40% of type 2 diabetes patients reduced HbA1c below diagnostic thresholds
More recently, we published research on our Wegovy-supported programme in JMIR Formative Research, showing that participants lost an average of 19.1% of body weight after 12 months.
Zava: Regulated prescription service
Zava operates as a streamlined online prescription service with GMC-registered doctors reviewing and approving medication requests.
Their approach focuses on providing efficient access to weight loss medications with appropriate medical oversight and essential written guidance on best practices and side effect management.
However, while they reference the clinical trial data for medications like Wegovy and Mounjaro, they don’t publish programme-specific research examining the effectiveness of their particular approach to weight management.
This means there’s no independently verified data on how their specific service affects long-term weight maintenance, especially after medication is discontinued.
Key points:
- Second Nature’s NHS partnerships now include expanded Tier 3 weight management services
- Recent research shows Second Nature achieves more than double the weight loss results of other programmes
- Zava is medically regulated but lacks programme-specific research on outcomes
Support & coaching
When taking weight-loss medications like Mounjaro or Wegovy, having the right support transforms your experience, helping you navigate side effects, adjust your eating patterns, and maintain motivation through challenges.
Second Nature: Comprehensive support system
At Second Nature, we provide access to UK-registered dietitians and nutritionists who specialise in supporting members on weight-loss injections.
These qualified professionals are available five days a week via both group and private chat as part of your standard programme cost.
Our health coaches receive specific training in side effect management, ensuring you receive personalised guidance through the physical and emotional challenges that sometimes arise during medication treatment.
We place you in a small group with others on similar journeys, creating a supportive community where you can share experiences and strategies.
We support mental health and behaviour change through:
- In-app psychological resources specifically for emotional eating
- Tips to build a positive relationship with sreess
- Expanded habit tracking and behaviour change tools
- Tools to find other ways of dealing with challenging emotions
Our programme is explicitly designed with post-medication life in mind:
- Focus on sustainable habit formation from your very first day
- Personalised transition plans for maintaining results after medication
- Ongoing access to support resources even after completing the programme
- Community support from others at similar stages
Zava: Self-guided medication management
Zava’s support model focuses primarily on the medical aspects of weight loss medication:
- Initial doctor review of your online consultation
- Written guidance on side effects and best practices
- Reactive support if you experience issues (patient-initiated)
- Self-guided implementation of lifestyle changes
While this approach ensures proper medical oversight, it places significant responsibility on patients to manage their own weight loss journey without structured professional guidance.
There is no built-in access to daily nutritionist-led coaching, peer support groups, or comprehensive digital tools for tracking habits and progress.
Follow-up care appears to be primarily reactive rather than proactive, with patients needing to initiate contact if they have questions or concerns.
Key points:
- Second Nature provides daily access to dietitians/nutritionists specialising in GLP-1 medications
- Enhanced psychological resources address emotional eating and stress
- Zava offers medical oversight but limited ongoing behavioural support
- Second Nature’s approach includes peer support and structured habit formation
Pricing & value
Understanding the full financial commitment helps you make an informed decision that aligns with both your health goals and financial circumstances.
Comprehensive pricing overview
Second Nature options:
- Without medication: From £33/month for a 12-month subscription (or £38/month for shorter terms)
- With Wegovy: £149-£249 monthly with £50 off the first month
- With Mounjaro: New prices to be confirmed in October
- Minimum commitment: £9.99 (14-day trial) for non-medication programme
Zava pricing:
- Wegovy: £179 for starter dose, rising to £275 for maintenance doses
- Mounjaro (likely to increase): £189 for starter doses, rising to £209 for higher doses
- Other medications: Saxenda and Orlistat also available
While Zava’s pricing may appear competitive, particularly for Mounjaro at higher doses, the value proposition differs significantly when considering the comprehensive support included with Second Nature.
At Second Nature, our monthly fee includes:
- Medication costs and delivery
- Daily access to registered dietitians and nutritionists
- Full access to our app with 300+ recipes
- Psychological resources for emotional eating and stress management
- Placement in peer support groups
- Post-medication transition planning
Zava’s offering includes:
- Medication costs and delivery
- Doctor review of your consultation
- Written guidance on medication use
- Reactive follow-up support
Key points:
- Second Nature offers a non-medication option from £33/month
- Zava’s pricing is primarily medication-focused without built-in support costs
- Second Nature’s Wegovy programme offers a £50 discount on the first month
- When comparing value, consider the long-term costs of weight regain without proper support
Frequently asked questions
How quickly can I get started with each programme?
Zava offers a streamlined process that can be completed entirely online, often with medication dispatched within 24-48 hours of prescription approval.
Second Nature typically has a similar timeline for starting medication, but also includes immediate access to the app, dietitian support, and programme materials. Both services require completion of a medical questionnaire and pharmacist review before medication is prescribed.
Will I regain weight after stopping Mounjaro or Wegovy?
Without proper support, research shows people regain approximately 68% of lost weight within a year of stopping GLP-1 medications.
However, with comprehensive habit change support like Second Nature’s programme, this regain can be significantly reduced. The habits you develop while on medication are the key determinant of long-term success.
Can I try Second Nature without medication first?
Yes, Second Nature offers a non-medication weight loss programme starting from £33/month for a 12-month subscription.
Many members achieve significant results without medication, and this can be a good option if you’re not yet eligible for GLP-1 medications or prefer to try lifestyle changes first.
You can always transition to the medication-supported programme later if needed.
What happens if I experience side effects with my medication?
Both services provide medical support for side effects, but the approach differs. With Zava, you need to initiate contact if you experience issues, and support is primarily through written guidance and reactive doctor communication.
Second Nature provides proactive support through daily access to dietitians who are specifically trained in managing GLP-1 medication side effects, plus peer group support from others experiencing similar challenges.
Take home message
Weight-loss medications like Mounjaro and Wegovy can be transformative when paired with the right support programme. They help silence food-related thoughts and provide the mental space to develop sustainable habits for long-term success.
When choosing between Zava and Second Nature, consider these key differences:
- Clinical credibility: Second Nature has seven years of NHS partnership and published research showing double the weight loss results of competitor programmes
- Support approach: Second Nature offers daily access to dietitians and enhanced psychological resources, while Zava provides medical oversight with self-guided implementation
- Digital integration: Second Nature features a comprehensive app with tracking tools, recipes, and resources, while Zava offers primarily written guidance
- Programme flexibility: Second Nature offers both medication and non-medication options starting from £33/month
- Long-term focus: Second Nature’s emphasis on habit formation and post-medication planning addresses the 68% weight regain commonly seen after stopping medications
The ultimate goal isn’t just losing weight in the short term; it’s making healthy habits feel second nature, becoming part of who you are rather than something you do for a limited time.
Ready to start your journey with the UK’s most trusted medication-supported weight-loss programme?
Take the eligibility quiz now →
Second Nature's Mounjaro and Wegovy programmes
Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes.
Why choose Second Nature over other medication providers, assuming you're eligible?
Because peace of mind matters.
We've had the privilege of working with the NHS for over eight years, helping people across the UK take meaningful steps toward a healthier, happier life.
Our programmes are designed to meet people where they are, whether that means support with weight loss through compassionate one-to-one health coaching, or access to the latest weight-loss medications (like Mounjaro and Wegovy) delivered alongside expert care from a multidisciplinary team of doctors, psychologists, dietitians, and personal trainers.
At the heart of everything we do is a simple belief: real, lasting change comes from building better habits, not relying on quick fixes. We're here to support that change every step of the way.
With over a decade of experience, thousands of lives changed, and a long-standing record of delivering programmes used by the NHS, we believe we're the UK's most trusted weight-loss programme.
We hope to offer you something invaluable: peace of mind, and the support you need to take that first step.
