Second Nature logo



How much weight can you lose in a month with Mounjaro?

Robbie Puddick
Written by

Robbie Puddick

Medically reviewed by

Fiona Moncrieff

3 min read
Last updated February 2024

Jump to: How much weight will I lose on Mounjaro? | Do you lose more weight on the higher doses of Mounjaro? | Second Nature’s Mounjaro-supported programme

According to data from randomised controlled trials, Mounjaro supports weight loss of around 4% of body weight after one month. After two months, it’s around 6% of body weight.

However, as this is an average rate of weight loss, it’s unclear how much weight loss an individual will lose in a month on Mounjaro. Some people may lose weight quickly, while others may take longer.

Tirzepatide (the active ingredient in Mounjaro) reduces appetite and hunger, helping you eat fewer calories; this effect is almost immediate.

However, you might notice the effect of lower hunger wearing off after 4-5 days post-injection in the first month of taking Mounjaro.

It can take 4-5 weeks for Mounjaro to reach a level in the body we call a steady state. A steady state is when the drug’s levels in the body remain consistent rather than spiking and falling.

Interestingly, this initial weight loss is no different to other weight loss treatments or the impact of diet interventions on weight loss. The real effect of tirzepatide is seen beyond three months.

Tirzepatide is a long-acting medication that’s started at a lower dose to reduce the number and severity of side effects as it builds up to a higher maintenance dose.

Mounjaro has now been approved for weight loss in the UK, and Second Nature will launch a Mounjaro-supported weight-loss programme in February 2024

Second Nature's Mounjaro Weight Loss Programme: Join our waiting list

Check my eligibility

How much weight will I lose on Mounjaro?

Research suggests that Mounjaro supports average weight loss of around 25% after one year. If you weighed 100kg, this would be a weight loss of 25kg.

However, as this is an average, it’s unclear how much weight each individual will be able to lose on Mounjaro.

The amount of weight people lose on Mounjaro will depend on how well they respond to the medication and their ability to make positive changes to their diet and lifestyle.

Do you lose more weight on the higher doses of Mounjaro?

Research suggests that higher doses of Mounjaro support more weight loss. One study compared the effects of Mounjaro 5 mg, 10 mg, and 15 mg on weight loss.

The results showed that Mounjaro 5 mg led to an average weight loss of 7.6kg after 40 weeks, 10 mg 9.3 kg, and 15 mg 11.2kg.

Mounjaro weight loss

These results suggest a linear relationship between the doses of Mounjaro and weight loss. So, the higher the dose, the greater the weight loss.

However, as we’ve discussed already, everyone responds differently to medication and how much weight you lose will depend on how well you respond to the medication and the changes you’re able to make to your lifestyle.

For example, some people may lose more weight on the lower doses of Mounjaro as they’re more sensitive to the drug’s effects and don’t need to increase the dosage.

Second Nature’s medication-supported programme

Second Nature has launched a medication-supported weight-loss programme for people who need the extra help to lose weight that Mounjaro and other weight-loss injections can provide.

Generally, we’d recommend trying our weight-loss programme before applying for a weight-loss injection. Not only is it cheaper (~£33 a month compared to ~£229), it may be more sustainable to focus on habits and behaviours without the medication.

However, if you’ve tried every diet and weight-loss program me under the sun and, despite your best efforts over many years, you still can’t find the solution to maintain your weight loss and lower your cravings. Our medication programme may be for you.

Our medication-supported programme offers:

  • Peace of mind that we’re the only weight-loss programme in the UK offering a medication-supported programme that’s also trusted by the NHS to deliver weight-loss services
  • 1-1 support from a registered nutritionist or dietitian
  • A guaranteed ongoing prescription for either Mounjaro or Wegovy that’s approved after a consultation with our clinical team

If you’d like to give Second Nature a go, the first step is to complete your health quiz to check your eligibility by clicking on the button below.

Second Nature's Mounjaro Weight Loss Programme: Join our waiting list

Check my eligibility

You might also like

Make losing weight feel Second Nature

The first step on your Second Nature journey is to take our health quiz.

Hand holding phone

Write a response

As seen on

The GuardianThe TimesChannel 4The Sunday Telegraph
Evening Standard