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Can you switch from Wegovy to Mounjaro?

Robbie Puddick
Written by

Robbie Puddick

Medically reviewed by

Fiona Moncrieff

3 min read
Last updated May 2024

Jump to: Do you lose more weight on Wegovy or Mounjaro? | How to switch to Mounjaro on Second Nature

You can switch from Wegovy to Mounjaro, but they’re not interchangeable, which means they can’t be used simultaneously.

Additionally, if you replaced Wegovy with Mounjaro, you might need to start at the lowest dose of Mounjaro and gradually titrate up to the higher doses.

This will depend on your current situation and whether our clinical team determine which dose is safe for you to transition to.

For example, if you’re on 2.4 mg of Wegovy (the highest dose) and switched to Mounjaro as part of Second Nature’s Mounjaro weight-loss programme, you might have to start on the lowest dose of Mounjaro, 2.5 mg.

However, our clinical team might determine that 5 mg of Mounjaro is safe for you to transition to if your current situation allows it.

After being on a higher dose of Wegovy, dropping to the lower doses of Mounjaro may be challenging. It’s possible your appetite might change during this transition as your body adjusts to the new medication.

Still, with the support and expertise of our registered nutritionists and clinicians, they were able to make this transition safely and effectively.

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Do you lose more weight on Wegovy or Mounjaro?

Data from randomised controlled trials suggests that Mounjaro leads to more average weight loss than Wegovy.

One study found that Mounjaro supported an average weight loss of nearly 25% after one year. If you weighed 100 kg, that would be a weight loss of 25 kg.

In comparison, research on Wegovy suggests it supports an average weight loss of around 16% after one year, 9% less than Mounjaro.

Additionally, research suggests the percentage of participants on Mounjaro achieving more than 10% weight loss is considerably higher than Wegovy.

Achieving over 10% weight loss is associated with clinically significant reductions in risk of chronic conditions such as type 2 diabetes and heart disease.

A randomised controlled trial in 670 people showed that 92% of participants on Mounjaro achieved more than 10% weight loss, with 84% achieving more than 15%.

In comparison, a randomised controlled trial in 1,961 people showed that 69% of participants on Wegovy achieved more than 10% weight loss, with 50% achieving more than 15%.

So, research suggests that Mounjaro leads to more average weight loss than Wegovy and may support more people achieving clinically significant weight loss of over 10%.

Switching from Wegovy to Mounjaro on Second Nature

Weight-loss injections are designed as additional tools for weight management interventions and shouldn’t be considered lifelong medications.

Instead, they should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.

Consider the use of antidepressants for people living with depression. They’re not designed to cure the condition. Instead, they’re designed to allow room for therapy to treat the condition’s underlying cause.

Mounjaro, and other weight loss injections, like Ozempic and Wegovy, are similar. They can allow you to make lifestyle changes to support long-term weight loss maintenance.

Mounjaro can help silence food-related thoughts and also give you a boost of confidence with more immediate weight-loss results.

This helps to buy you the time and headspace to understand why your body may have struggled to lose weight previously, and to build new long-term healthy habits.

The core focus of our medication programmes is to calm down the feeling of food noise, lower your cravings, and allow you to build healthier habits to keep the weight off for good.

The ultimate goal is to make losing weight feel second nature.

Second Nature’s medication-supported programmes

Second Nature has two medication-supported programmes: a Wegovy weight-loss programme and a Mounjaro weight-loss programme.

If you’ve made the decision to switch from Wegovy to Mounjaro (assuming you’re eligible), why should you choose Second Nature over other medication providers?

For peace of mind.

Second Nature has worked with the NHS for over 6 years providing weight-loss programmes across the UK.

Whilst our Wegovy and Mounjaro weight-loss programmes are private and not currently used by the NHS, we’ve built the programmes with a focus on scientific evidence, patient safety, and data security.

We hope that our 6+ years of working with the NHS and building a track record of effective weight-loss results will give you peace of mind to give us a try.

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