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Can you switch from Saxenda to Mounjaro?

Robbie Puddick
Written by

Robbie Puddick

Medically reviewed by

Fiona Moncrieff

3 min read
Last updated February 2024

Jump to: Do you lose more weight on Saxenda or Mounjaro? | How to switch to Mounjaro from Saxenda on Second Nature

You can switch from Saxenda to Mounjaro, but they’re not interchangeable, which means they can’t be used simultaneously.

Additionally, if you replaced Saxenda with Mounjaro, you’d need to start at the lowest dose of Mounjaro and gradually titrate up to the higher doses on Second Nature’s medication weight-loss programme.

For example, if you’re on 3 mg of Saxenda and switched to Mounjaro with Second Nature, you’d have to start on the lowest dose of Mounjaro, 2.5 mg.

How to switch from Saxenda to Mounjaro

Having to start at the lowest dose is due to Mounjaro’s strict treatment protocol on Second Nature.

Mounjaro is a new medication in the UK, and our clinical team will only approve prescriptions for individuals starting at a dose of 2.5 mg.

After being on a higher dose of Saxenda, dropping to the lowest dose of Mounjaro may be challenging.

It’s possible your appetite and side effect profile may change during this transition as your body adjusts to the new medication.

Still, with the support and expertise of our registered nutritionists and clinicians, they were able to make this transition safely and effectively.

Research has shown that switching from one type of GLP-1 medication (like Saxenda) to another (like Mounjaro) can provide health benefits such as improved blood sugar levels and weight loss.

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Do you lose more weight on Saxenda or Mounjaro?

Research suggests that Mounjaro leads to around 15% more weight loss than Saxenda.

Studies have shown that Saxenda leads to an average weight loss of 6.4%. Comparatively, Mounjaro leads to a weight loss of up to 25%.

The more significant weight loss we generally see with Mounjaro is likely due to its dual action of mimicking GLP-1 and GIP hormones.

Additionally, research has shown that long-acting GLP-1 weight-loss injections like Mounjaro are more effective than short-acting ones like Saxenda.

Mounjaro’s active ingredient, tirzepatide, maintains a higher level in the body over a sustained period, so it’s only injected once a week.

Saxenda, in comparison, is injected daily, and its levels are more likely to rise and fall in the body.

Switching from Saxenda to Mounjaro on Second Nature

Second Nature has launched a medication-supported weight-loss programme for people who need the extra help to lose weight that Mounjaro and other weight-loss injections can provide.

Generally, we’d recommend trying our weight-loss programme before applying for a weight-loss injection.

Not only is it cheaper (~£33 a month compared to ~£229), it may be more sustainable to focus on habits and behaviours without the medication.

However, if you’ve tried every diet and weight-loss programme under the sun and, despite your best efforts over many years, you still can’t find the solution to maintain your weight loss and lower your cravings. Our Mounjaro weight-loss programme may be for you.

Our Mounjaro weight-loss programme offers:

  • Peace of mind that we have over 7 years of experience delivering weight-loss services in the UK and adhere to the highest standards of clinical safety
  • 1-to-1 support from a registered nutritionist or dietitian
  • A guaranteed ongoing prescription for Mounjaro if you’re approved after a consultation with our clinical team
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