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Should I buy a weight-loss injection from the Mayfair Weight Loss Clinic?

Robbie Puddick
Written by

Robbie Puddick

Medically reviewed by

Fiona Moncrieff

5 min read
Last updated February 2024

Jump to: Should I buy Wegovy online? | Weight regain with Wegovy | Second Nature’s NHS-trusted | Cost and Trustpilot reviews | Take home message

This article is accurate to the best of our knowledge as of October 2023.

Whether you choose to purchase a weight-loss injection from the Mayfair Weight Loss Clinic will depend on the level of support you feel you need alongside the medication.

The Mayfair Weight Loss Clinic’s website advertises Wegovy with a doctor-approved prescription.

Still, it’s not clear whether the medication comes with a programme or ongoing support from a healthcare professional to help you on your weight-loss journey.

Research shows that when semaglutide (Wegovy) treatment is stopped, weight regain is very likely if the underlying habits and behaviours that led to weight gain in the past are addressed.

Second Nature’s medication-supported programme offers several benefits alongside a semaglutide prescription:

  • Peace of mind that we’ve been trusted by the NHS since 2017 to provide weight-loss services
  • Access to a registered nutritionist or dietitian five days a week
  • Science-backed articles to help you keep the weight off for good
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Should I buy Wegovy online?

Wegovy is designed as an additional tool for weight management and shouldn’t be considered a lifelong medication.

Instead, it should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.

Ideally, we’d be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term.

We’d generally recommend trying Second Nature’s weight-loss programme before considering a weight-loss jab.

Changing your habits is the most sustainable way to achieve long-term weight loss, and it’s also less expensive (£40 a month vs. ~£299 a month).

At Second Nature, we’ve been trusted by the NHS since 2017 to support people with type 2 diabetes and obesity to lose weight, manage their blood sugar levels, and lead healthier lifestyles for the long term.

In 2022, the NHS published data in the BMJ that compared the weight loss outcomes of five providers in the National Diabetes Prevention Programme.

Second Nature was more than twice as effective at supporting weight loss than the other four providers.

However, if you’ve decided to try Wegovy (when it’s available) but need support in making positive changes to your lifestyle, Second Nature could be an option for you. But it’s worth noting that we have strict eligibility criteria.

Otherwise, keep reading as we look at three reasons you might consider joining our programme.

1) Weight regain with Wegovy is likely without the proper support

Like traditional diets, where participants typically regain weight once the diet program ends, weight regain is significant following the cessation of semaglutide.

The greater the initial weight loss, the more significant the weight regained.

However, those who lose more weight initially maintain more significant weight loss compared to baseline than those who lose less before the medication is withdrawn.

In this post-analysis of 327 participants, the average weight loss after 68 weeks was 17.3% with semaglutide and 2% with placebo.

After 52 weeks of follow-up, after the medication was withdrawn, the average weight loss was 5.6% with semaglutide and 0.1% with placebo.

A weight regain of 11.6% in the semaglutide group and 1.9% in the placebo.

Weight regain isn’t inevitable. Long-term sustainable weight loss can be achieved, but you need the proper support.

It’s unclear whether you’ll receive this level of support with the Mayfair Weight Loss Clinic as there’s no clear mention of this alongside the medication on their website.

While on the medication, you’ll likely lose weight, as evidence shows that semaglutide is extremely effective at reducing appetite and helping you eat fewer calories. 

However, it’s likely that when you come off the medication, you’ll regain much of the lost weight without making significant changes to your habits and lifestyle.

But support is something that Second Nature can offer, and the fact we’ve been trusted by the NHS since 2017 to provide weight-loss services showcases the long-term impact Second Nature has had on our members.

2) Second Nature’s NHS-trusted and NICE-approved

Second Nature has been trusted by the NHS since 2017. We’ve delivered programmes for the NHS in type 2 diabetes management, diabetes prevention, and weight management.

The National Institute of Health and Care Excellence (NICE) recently announced that Wegovy would be available via digital weight management services provided by Second Nature and three other companies supporting the NHS.

This approval recognises the high level of patient care and support that Second Nature has provided our members.

The Mayfair Weight Loss Clinic doesn’t advertise a weight-loss programme alongside a Wegovy prescription on its website.

Interestingly, there’s no research on the impact of Wegovy without a lifestyle change programme being implemented alongside the weight-loss injection.

3) Wegovy cost and Trustpilot reviews

  • The total monthly cost of the Second Nature programme, including semaglutide medication, is £229, rising to £299
  • The total monthly cost of Wegovy from the Mayfair Weight Loss Clinic is £199 for the lower doses, rising to £319 for the maintenance dose
  • Second Nature’s current Trustpilot score based on 6,270 reviews is 4.8, and are rated as ‘Excellent’
  • The Mayfair Weight Loss Clinic’s Trustpilot score (as of October 2023) based on 42 reviews is 3.7 and is rated as ‘Average’. However, their account isn’t verified.

Take home message

Weight-loss injections like Wegovy (semaglutide) can be extremely effective. However, they’ve only been shown to support weight loss alongside a lifestyle change programme.

It’s unclear what the impact of using Wegovy in isolation without the support of healthcare professionals will be.

HealthExpress may offer ongoing support in some form, but this isn’t stated clearly on their website as of October 2023.

So, if you’ve decided to lose weight with the support of a weight-loss jab like Wegovy, we’d recommend giving Second Nature a go.

Wegovy information

Product name Wegovy
Active ingredient Semaglutide
Manufacturer Novo Nordisk
Price £229
What’s included?
    • Access to a registered nutritionist or dietitian five days a week via our award-winning app
    • Weighing scales and our hardback recipe book
    • Peace of mind that we’re the only Wegovy provider who’s also trusted by the NHS to deliver weight-loss services
Second Nature Trustpilot rating 4.8/5
Second Nature Trustpilot reviews 6,888 (as of January 2024)
Availability In stock
Description Once weekly weight-loss injection
Administration Subcutaneous injection (multiple sites like the arm, stomach, or leg)
Presentation Injection pen
Available dosage 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4 mg
Drug class GLP-1 receptor agonist
When pregnant/breastfeeding Not permitted


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