You can take Mounjaro if you’re currently living with high blood pressure and obesity. Research shows that tirzepatide (the drug in Mounjaro) significantly reduces systolic and diastolic blood pressure by around 7 mmHg and 4 mmHg on average1.
In randomised controlled trials, the percentage of participants with normal blood pressure increased from 30.2% to 58% after 72 weeks of treatment2, suggesting a positive impact of the medication on blood pressure.
Important safety information: Mounjaro (tirzepatide) is a prescription-only medication for treating type 2 diabetes and managing obesity. This article is for informational purposes only. Always consult with your healthcare provider before starting any new medication, particularly if you have had your gallbladder removed or have other health conditions.
Mounjaro can help to lower blood pressure in people living with obesity, though individual responses vary. In practice, this means you might see improvements in both your weight and blood pressure readings during treatment3.
However, it’s important to note that these clinical trials had specific eligibility criteria, and results may differ based on your personal health circumstances.
If you’re not living with obesity but have high blood pressure, you won’t be prescribed Mounjaro as it could lead to excessive weight loss that may prevent you from maintaining a healthy weight.
In this scenario, you may need to naturally lower your blood pressure or speak with your doctor about other options.
Key blood pressure findings from clinical research:
- Average systolic reduction: 7 mmHg1
- Average diastolic reduction: 4 mmHg1
- Increase in normal blood pressure: from 30.2% to 58% of participants2
- Blood pressure reduction appears consistent across different patient subgroups4
- Effects may be partially independent of weight loss5
Are there any risks associated with taking Mounjaro if you have high blood pressure?
While Mounjaro generally shows positive effects on blood pressure, it’s important to understand the potential risks and side effects that may affect people with hypertension1,2.
In clinical trials, around 6.8% of participants experienced at least one blood pressure-related event. The most common were:
- Dizziness (4.6%)
- Hypotension or low blood pressure (1%)
- Syncope – temporary loss of consciousness (0.5%)
For most people, these effects were mild and temporary. However, for individuals already taking blood pressure medications, there’s an increased risk of experiencing low blood pressure, especially during the initial weeks of treatment or during dose increases6.
The Medicines and Healthcare products Regulatory Agency (MHRA) advises that patients with the following conditions should exercise additional caution when considering Mounjaro6:
- Severe or unstable hypertension
- History of significant orthostatic hypotension (blood pressure drop when standing)
- Recent cardiovascular events (within 6 months)
- Multiple blood pressure medications, particularly if recently adjusted
While no severe adverse events were reported in the blood pressure sub-studies, it’s worth noting that initial clinical trials excluded people with uncontrolled hypertension (>160/100 mmHg).
If your blood pressure is above this threshold, your healthcare provider may recommend getting your blood pressure better controlled before starting Mounjaro1.
Research suggests that over 90% of people on Mounjaro with high blood pressure will experience no adverse events from the medication, and any adverse events are likely to be mild and transient.
Can you take Mounjaro with blood pressure medications?
You can take Mounjaro with blood pressure medications3.
However, it’s recommended that you monitor your blood pressure closely, as the combination of Mounjaro with other blood pressure-lowering medications may increase the risk of adverse blood pressure-related events like hypotension, syncope (a gradual loss of consciousness and muscular tone), and dizziness.
Your doctor will likely monitor your response to the effects of Mounjaro, along with blood pressure medications, more carefully than patients without hypertension.
If your blood pressure starts to decline in response to the treatment, they may lower your blood pressure medication dose to avoid adverse events6. In practice, this means:
- Having more frequent blood pressure checks in the first 3 months
- Possibly monitoring your blood pressure at home
- Reporting any dizziness or lightheadedness promptly to your doctor
- Being prepared for potential adjustments to your existing medications
Never adjust your blood pressure medications yourself without consulting your healthcare provider.
How can Mounjaro lower blood pressure?
The exact mechanisms of how Mounjaro lowers blood pressure are yet to be fully discovered.
However, it’s well known that obesity and obesity-related conditions like type 2 diabetes significantly increase the risk of developing high blood pressure (hypertension).
The causes and factors influencing blood pressure are complex. Still, one problem observed in people with high blood pressure is that their kidneys seem to hold onto more sodium, which can lead to the body retaining excess water, increasing blood pressure over time4.
Another issue is vasoconstriction, where your blood cells ‘tighten’ or ‘stiffen’, making it difficult for blood to flow through your system. To counter this effect, your heart has to pump harder (increasing blood pressure).
So, if we can improve our kidneys’ ability to excrete excess sodium, manage fluid balance, and reduce vessel stiffening, we’ll likely see improvements in blood pressure.
Research has shown that high insulin levels (insulin resistance) can also cause the kidneys to hold onto more sodium and increase blood pressure7.
So, one possible way that Mounjaro may lower blood pressure is by reducing insulin levels and insulin resistance, which helps the body excrete more sodium from the kidneys, thereby lowering blood pressure over time.
Recent studies suggest that tirzepatide may also have direct effects on the blood vessels themselves, potentially through its dual action on GLP-1 and GIP receptors4,5.
In fact, analysis of the SURPASS trials showed that 33-57% of blood pressure reduction may be independent of weight loss4.
Read our guide on how to lower blood pressure to understand blood pressure and how to treat it in more detail.
How to monitor your blood pressure while taking Mounjaro
If you have high blood pressure and are starting Mounjaro, regular monitoring becomes particularly important. Research shows that blood pressure changes can occur within the first few weeks of treatment1,5.
The National Institute for Health and Care Excellence (NICE) recommends the following monitoring approach for patients with hypertension who are starting weight-loss medications3:
- Establish a baseline blood pressure reading before starting treatment
- Check blood pressure at each dose escalation appointment
- Once on a stable dose, monitor blood pressure at least monthly for the first three months
- After three months, continue monitoring according to your usual hypertension care plan
Many patients find home blood pressure monitoring helpful. If you choose this approach:
- Use a validated upper arm cuff monitor (wrist monitors are generally less accurate)
- Take readings at the same time each day, ideally in the morning
- Take 2-3 readings each time and record the average
- Bring your readings to appointments with your healthcare provider
- Alert your healthcare team if you notice significant changes (>20 mmHg systolic or >10 mmHg diastolic)
It’s important to note that as your blood pressure improves, you may need adjustments to your existing blood pressure medications. Never adjust these medications yourself and always consult with your healthcare provider.
How Mounjaro compares to other medications for blood pressure effects
Understanding how Mounjaro’s effects on blood pressure compare to other weight-loss medications can help you have informed discussions with your healthcare provider. The table below summarises current evidence4,5.
| Medication |
Average systolic BP reduction |
Average diastolic BP reduction |
Additional considerations |
| Mounjaro (tirzepatide) |
7-10.6 mmHg |
4-5 mmHg |
May slightly increase heart rate by 2-5 beats per minute |
| Wegovy/Ozempic (semaglutide) |
3.5-5.0 mmHg |
2-3 mmHg |
Smaller BP reduction compared to tirzepatide |
| Traditional BP medications |
5-10 mmHg (varies by class) |
3-8 mmHg (varies by class) |
Specifically designed for BP management |
| Diet and exercise alone |
4-5 mmHg |
2-4 mmHg |
Results vary significantly between individuals |
The data suggest that Mounjaro may offer blood pressure benefits comparable to some traditional anti-hypertensive medications, while also supporting weight management.
However, it’s important to remember that Mounjaro is not approved specifically for blood pressure treatment, and these effects should be considered a beneficial secondary outcome rather than the primary treatment goal3.
Frequently asked questions
Will Mounjaro interact with my blood pressure medications?
Mounjaro doesn’t have direct drug interactions with common blood pressure medications. However, as Mounjaro may lower your blood pressure, the combined effect with your existing medications could potentially cause it to drop too low.
Your doctor may need to adjust your blood pressure medication dosage as you lose weight and your blood pressure improves6.
How quickly will Mounjaro affect my blood pressure?
Clinical studies suggest blood pressure improvements can begin within weeks of starting treatment, with maximum effects typically seen after 3-6 months.
The effects appear to be partially related to weight loss, but some evidence suggests there may be direct beneficial effects on blood vessels independent of weight loss4,5.
Should I stop my blood pressure medications when starting Mounjaro?
No. Never discontinue prescribed medications without consulting your healthcare provider. Your doctor will monitor your blood pressure and make appropriate adjustments to your medications based on your response to treatment.
Is the blood pressure-lowering effect of Mounjaro permanent?
The blood pressure benefits appear to be maintained as long as you continue taking Mounjaro and maintain healthy habits.
However, if you stop the medication and regain weight, your blood pressure may return to previous levels. This highlights the importance of developing sustainable lifestyle habits while on treatment1,2.
Does Mounjaro work better for blood pressure than other GLP-1 medications?
Some comparative studies suggest that tirzepatide (Mounjaro) may have a stronger effect on blood pressure than semaglutide (Ozempic/Wegovy). This might be due to its dual action on both GLP-1 and GIP receptors. However, individual responses vary, and what works best depends on your specific situation4.
Can Mounjaro cause dangerously low blood pressure?
While rare, significant hypotension (low blood pressure) can occur, especially in people already taking multiple blood pressure medications.
Signs of low blood pressure include dizziness, lightheadedness, fainting, or unusual fatigue. Contact your healthcare provider immediately if you experience these symptoms6.
Is it safe to exercise while taking Mounjaro if I have high blood pressure?
Exercise is generally beneficial for both weight management and blood pressure control. However, if you’ve recently started Mounjaro and have a history of hypertension, begin with moderate activity and monitor how you feel.
Some people experience dizziness during the initial weeks of treatment, so it’s wise to avoid high-intensity exercise until you understand how your body responds5.
Do I need more frequent blood pressure monitoring on Mounjaro?
If you have hypertension and start Mounjaro, more frequent monitoring is recommended, especially during the first three months and during dose adjustments. Home blood pressure monitoring can be valuable in tracking your response to treatment3.
Take home message
Mounjaro can be an effective option for people living with both obesity and high blood pressure, with clinical evidence showing significant reductions in blood pressure alongside weight loss1,2.
The key points to remember are:
- Mounjaro typically reduces systolic blood pressure by 7-10 mmHg and diastolic blood pressure by 4-5 mmHg in clinical trials
- Regular blood pressure monitoring is essential, especially during the first three months
- Work closely with your healthcare provider to adjust any existing blood pressure medications as needed
- Most blood pressure-related side effects are mild, with severe adverse events being rare
- The blood pressure benefits appear to persist as long as treatment continues
If you’re living with obesity and hypertension, a comprehensive approach that includes appropriate medication, dietary changes, regular physical activity, and stress management offers the best chance for long-term health improvements.
Second Nature's Mounjaro and Wegovy programmes
Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes.
Why choose Second Nature over other medication providers, assuming you're eligible?
Because peace of mind matters.
We've had the privilege of working with the NHS for over eight years, helping people across the UK take meaningful steps toward a healthier, happier life.
Our programmes are designed to meet people where they are, whether that means support with weight loss through compassionate one-to-one health coaching, or access to the latest weight-loss medications (like Mounjaro and Wegovy) delivered alongside expert care from a multidisciplinary team of doctors, psychologists, dietitians, and personal trainers.
At the heart of everything we do is a simple belief: real, lasting change comes from building better habits, not relying on quick fixes. We're here to support that change every step of the way.
With over a decade of experience, thousands of lives changed, and a long-standing record of delivering programmes used by the NHS, we believe we're the UK's most trusted weight-loss programme.
We hope to offer you something invaluable: peace of mind, and the support you need to take that first step.
References
- de Lemos, J.A., et al. (2024). Tirzepatide Reduces 24-Hour Ambulatory Blood Pressure in Adults With Body Mass Index ≥27 kg/m2: SURMOUNT-1 Ambulatory Blood Pressure Monitoring Substudy. Hypertension
. 2024 Apr;81(4):e41-e43.
- Jastreboff, A.M., et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205-216.
- National Institute for Health and Care Excellence. (2025). Tirzepatide for managing overweight and obesity (TA1026).
- Lingvay, I., et al. (2023). Systolic blood pressure reduction with tirzepatide in patients with type 2 diabetes: insights from SURPASS clinical program. Cardiovascular Diabetology, 22(1), 66.
- Grunberger, G., et al. (2023). Tirzepatide and blood pressure reduction: stratified analyses of the SURMOUNT-1 randomised controlled trial. The Lancet Diabetes & Endocrinology.
- Medicines and Healthcare products Regulatory Agency. (2025). Drug Safety Update: Tirzepatide (Mounjaro): monitoring and management of adverse effects.
- Reaven, G.M., et al. (1997). Renal effects of insulin in man. J Nephrol
. 1997 Jul-Aug;10(4):188-91.
