Your Foundayo contraception calendar
Start using extra contraception on the day you take your first Foundayo tablet, and keep using it for 30 days.
Each time your dose goes up, use extra contraception for another 30 days, counting from your first tablet of the new dose.1
Foundayo starts at 0.8 mg a day. After at least 30 days, your dose should go up to 2.5 mg, and after at least another 30 days, it can go up to 5.5 mg.1
Each dose increase after that, to 9 mg, 14.5 mg, and 17.2 mg, also takes at least 30 days and depends on how well Foundayo is working for you and how well you tolerate it.1 So, if you stay on 2.5 mg, you’ll need extra contraception for 60 days in total. If you go all the way up to 17.2 mg, you’ll need it for 180 days in total.
The table below shows the dates you’d need extra contraception if you took your first tablet on 2nd November 2026 and increased your dose every 30 days, which is the fastest the prescribing information allows.
| Dose |
Earliest start |
Use extra contraception until (with our added day) |
Days on Foundayo |
| 0.8 mg |
2 November 2026 |
2 December 2026 |
1 to 31 |
| 2.5 mg |
2 December 2026 |
1 January 2027 |
31 to 61 |
| 5.5 mg |
1 January 2027 |
31 January 2027 |
61 to 91 |
| 9 mg |
31 January 2027 |
2 March 2027 |
91 to 121 |
| 14.5 mg |
2 March 2027 |
1 April 2027 |
121 to 151 |
| 17.2 mg |
1 April 2027 |
1 May 2027 |
151 to 181 |
We’ve counted your first tablet as day 1. The prescribing information says “30 days after” but doesn’t explain how to count the days, so we recommend adding 1 day to allow for a strict reading, and the table includes it.
In this example, your last day of extra contraception would be 1st May 2027. That covers the 180 days from the prescribing information, plus our extra day.
If you stay on a dose for longer
You may stay on a dose for longer than 30 days if it’s working well or you’re struggling with side effects. Once a 30-day period ends, the prescribing information doesn’t recommend extra contraception again until your next dose increase.
For example, if you stayed on 5.5 mg for 90 days and increased to 9 mg on 1st April 2027, you wouldn’t need extra contraception from 1st February to 31st March 2027. You’d use it again from 1st April to 1st May 2027.
Which contraceptive pills need extra contraception with Foundayo?
You’ll need extra contraception whether you take the combined pill or the progestogen-only pill, whatever the brand, hormone, or dose. The UK prescribing information says Foundayo “may reduce the efficacy of oral hormonal contraceptives”, and it makes no exceptions.1
The combined pill, such as Microgynon, contains an oestrogen and a progestogen. The progestogen-only pill, such as Cerazette, contains only a progestogen.
If you’re not sure which type you take, your pack or leaflet lists the hormones it contains.
We don’t know whether one type of pill works better with Foundayo, because neither has been tested in people taking it.
The only evidence comes from a computer model that Lilly, the company that makes Foundayo, used to predict how it would affect the hormones in a combined pill.3
The emergency contraceptive pill
We don’t know whether Foundayo affects the emergency contraceptive pill, and the UK prescribing information gives no advice on it.1
The College of Sexual and Reproductive Healthcare (formerly the FSRH), which publishes UK contraception guidance, found no evidence on this for the GLP-1 medications it reviewed, which didn’t include Foundayo.4
If you’re relying on the pill during a 30-day period and have sex without a condom, or a condom splits or comes off, you may need emergency contraception. Go to a pharmacy or sexual health clinic as soon as you can, as it usually works better the sooner you use it.
The NHS lists three options: levonorgestrel (Levonelle) within 3 days of sex, ulipristal acetate (ellaOne) within 5 days, or a copper coil fitted within 5 days, which is the most effective. Most sexual health clinics and GP surgeries offer these for free, and most pharmacies offer the emergency pill for free.
Your weight can affect which emergency contraception will work best for you. Levonorgestrel could work less well if your body mass index (BMI) is over 26 or you weigh more than 70 kg, which includes everyone who meets the UK criteria to start Foundayo for weight management.5,1
In this situation, the College recommends ulipristal or a double dose of levonorgestrel (3 mg), and says it isn’t known which works better. The copper coil isn’t known to be affected by weight.5
The contraceptive pill you usually take can also affect which emergency contraception will work best for you.
Both types of pill contain a progestogen, and taking a progestogen in the 7 days before or the 5 days after ulipristal could make ulipristal less effective.5
If you’re offered ulipristal, ask the pharmacist whether to keep taking your pill and how long to use condoms. After levonorgestrel, you can carry on with your pill straight away.5
Tell the pharmacist or clinic that you’re taking Foundayo and which pill you take, so they can help you choose.
Bleeding on hormonal contraception may not be a true period, so if you carry on with or restart your pill, take a pregnancy test 21 days after you last had sex without a condom. Also take a test if your next period is more than 7 days late, is lighter than usual, or comes with unusual stomach pain.5
Why do you need extra contraception when taking Foundayo?
Foundayo is a daily GLP-1 tablet that slows how quickly our stomach empties.1 According to the U.S. prescribing information, slower stomach emptying may reduce how much of the contraceptive pill our body absorbs, which is why extra contraception is advised.2
The UK regulator, the MHRA, hasn’t published its reasons for its recommendations, so we can infer that the UK guidelines are based on the same evidence as the U.S. advice.
No study has tested Foundayo with the pill.2 The evidence the U.S. regulator, the FDA, reviewed was a paracetamol study, a computer simulation, and what happened when Mounjaro (tirzepatide), a weekly injection that also slows how quickly our stomach empties, was taken with the pill.36
The contraceptive pill only prevents pregnancy if enough of its hormones get into our bloodstream.7 Researchers measure this in two ways: the total amount of each hormone that reaches the blood over a day, and the highest level it reaches after each pill.
According to the College of Sexual and Reproductive Healthcare, if another medicine lowers that highest level below a certain point, the pill may be less effective at preventing pregnancy.4 Neither measure tells us whether someone becomes pregnant.
To measure how much Foundayo slows stomach emptying, researchers gave people paracetamol.
Paracetamol is absorbed once it leaves the stomach, so how quickly it reaches the blood shows how quickly the stomach is emptying.3
When people took paracetamol with their first 0.8 mg dose of Foundayo, their highest blood paracetamol level was 28% lower.12
Foundayo slowed stomach emptying most after the first dose, and the effect became smaller the longer people took it.1
However, you still need extra contraception for 30 days after every dose increase. The paracetamol trials show how quickly the stomach empties, not how well the contraceptive pill is absorbed, and the UK prescribing information still advises extra contraception after each increase.1
Foundayo’s manufacturer, Lilly, used a computer simulation rather than a clinical trial to predict what would happen with a combined pill.23 This type of simulation uses data from earlier studies to predict how a medicine moves through the body.3
The simulation predicted that each hormone would reach the blood more slowly, with no change in the total amount, at both the first and highest Foundayo doses.3
It predicted that the highest hormone levels would be 10% to 24% lower at the first dose, and 4% to 7% lower at the highest licensed dose in people with obesity or overweight.3 These were predictions, not measurements in people.
Lilly concluded that Foundayo wasn’t expected to affect the pill’s safety or how well it works.
The FDA disagreed and recommended that the U.S. label state that the highest level of paracetamol in the blood was 28% lower after the first dose of Foundayo, and advise switching contraception or adding a barrier method.3
The FDA questioned the simulation because the same method had predicted almost no change in the total amount of each hormone when Mounjaro was taken with a combined pill.3
Yet, when researchers measured this in people, they found 20% less oestrogen and 23% less progestogen.6
The method had accurately predicted Mounjaro’s effect on paracetamol but missed its effect on the pill. The FDA concluded that the method may show whether hormone levels will rise or fall, but its estimate of how much they change may be inaccurate.3
The UK prescribing information says a computer model predicted that Foundayo wouldn’t change the levels of commonly used medicines enough to matter.
Even so, the same section advises extra contraception for 30 days after starting Foundayo and after each dose increase.1
Because the same computer modelling method missed the fall in hormone levels with Mounjaro, we don’t think its predictions for Foundayo show that the pill works as usual, so we recommend using extra contraception throughout every 30-day period.
Do Mounjaro and Wegovy need extra contraception too?
Mounjaro and Wegovy (semaglutide) also slow how quickly our stomach empties, so they could also affect how well the contraceptive pill is absorbed.
Mounjaro’s prescribing information advises extra contraception for 4 weeks after starting and after each dose increase, because a study found that the levels of the pill’s hormones in the blood fell after a single dose of Mounjaro.6
Wegovy’s prescribing information doesn’t advise extra contraception, because studies found that semaglutide didn’t lower the levels of the pill’s hormones.8
| Medication |
UK advice with the pill |
Evidence with the pill |
| Foundayo |
Extra contraception for 30 days after starting and after each dose increase |
Computer simulation only |
| Mounjaro |
Extra contraception for 4 weeks after starting and after each dose increase |
Measured after a single dose: total oestrogen in the blood 20% lower |
| Wegovy injection |
No extra contraception needed, apart from your pill’s sickness advice |
Measured at 1.0 mg: the pill’s hormone levels didn’t fall |
| Wegovy pill |
No extra contraception needed, apart from your pill’s sickness advice |
Measured with oral semaglutide 14 mg: the pill’s hormone levels didn’t fall |
The Mounjaro study gave 40 women a single 5 mg dose with a combined pill,4 and the highest blood level of the pill’s oestrogen was 59% lower.6
Mounjaro’s prescribing information says this fall isn’t large enough to matter in practice after one dose, but there’s limited information on women living with overweight or obesity, so the pill may work less well for them.6
The semaglutide studies enrolled 43 women on a 1.0 mg injection, 39 of whom finished, and 25 on 14 mg tablets, a lower dose than the 25 mg Wegovy pill.78 Both used a different combined pill from the Mounjaro study.6
Neither study found a fall in the pill’s hormones, and the College of Sexual and Reproductive Healthcare, which publishes UK contraception guidance, says there’s no need to add a barrier method with semaglutide.7,8,4
Both studies measured hormone levels after weeks of semaglutide, once its level in the body had stabilised.7,8 The Mounjaro study measured the effect of a single dose, and its prescribing information says the effect on absorption is strongest when treatment starts.6
The semaglutide studies were also in postmenopausal women, chosen so that monthly hormone changes wouldn’t affect the results, and the oral semaglutide study only included people with a BMI of 20 to 29.9.7,8
So, these studies tell us little about the first weeks of treatment, and they didn’t test women who could become pregnant.
No study has tested Foundayo with the contraceptive pill yet. Until one does, we recommend assuming that Foundayo could lower the pill’s hormone levels, as Mounjaro does, so use extra contraception for 30 days after starting Foundayo and after each dose increase.
The Wegovy pill doesn’t need extra contraception, but that doesn’t make it a safer medicine than Foundayo overall. Our Wegovy pill and Foundayo comparison covers the wider differences.
Changing to a non-oral contraceptive method
If using condoms for several months isn’t possible, we recommend speaking with your prescriber or clinic about a non-oral method before you start Foundayo.
Once your new non-oral method is working, you can use it without extra contraception during the 30-day periods.
The U.S. prescribing information says hormonal contraceptives that aren’t taken by mouth shouldn’t be affected,2 although the UK prescribing information doesn’t say this directly.1
Your BMI also affects which methods are suitable; Foundayo is licensed for weight management at a BMI of 30 or above, or 27 or above with a weight-related health condition.1
The risk of blood clots rises with BMI. The combined pill, patch, and ring also raise this risk, and slightly raise the risk of a heart attack or stroke. At a BMI of 35 or above, the College of Sexual and Reproductive Healthcare says the risks of these three methods generally outweigh the benefits.9
That’s why UKMEC, the UK guidance on who can safely use each contraceptive, gives them a score of 3 at this BMI, meaning they’re usually only recommended if other methods aren’t suitable. A score of 2 means the advantages generally outweigh the risks, and 1 means no restriction.10
| Method |
What it involves |
How well it works with typical use |
UKMEC score at BMI 30 to 34.9, then 35 or above |
| Copper coil |
A small T-shaped device fitted in your womb, lasting 5 or 10 years |
Over 99% |
1 at both |
| Hormonal coil |
A small T-shaped device fitted in your womb, lasting 3 to 8 years |
Over 99% |
1 at both |
| Implant |
A small rod put under the skin of your arm, lasting 5 years |
Over 99% |
1 at both |
| Injection |
An injection every 8 to 13 weeks, depending on the type |
94% |
1, then 2 |
| Patch |
A patch you wear on your skin and replace every 7 days |
91% |
2, then 3 |
| Vaginal ring |
A soft plastic ring you leave in your vagina for 3 weeks |
91% |
2, then 3 |
| Combined pill |
A tablet you need to remember to take |
91% |
2, then 3 |
| Progestogen-only pill |
A tablet you need to remember to take |
91% |
1 at both |
The percentages in the table are the NHS figures for typical use. This includes pregnancies caused by mistakes, such as missing a pill or forgetting to replace a ring. They don’t show how well the pill works when you’re taking Foundayo.
Other factors, such as smoking, can change these scores.10 If you take the combined pill and your BMI is 35 or above, we recommend speaking with your GP or sexual health clinic about your contraception, whatever you decide about Foundayo.
After the injection, it can take up to 1 year for your fertility to return, so it may not suit you if you’re planning a pregnancy. It also appears to be linked to some weight gain, particularly in under-18s with a BMI of 30 or above.9
The copper coil works as soon as it’s fitted. The implant, injection, and hormonal coil protect you straight away if you have them in the first 5 days of your cycle. If not, use condoms for 7 days.
If you change method during a 30-day period, we recommend using condoms until your clinic says you can stop, because the usual advice on changing method assumes your pill has been working as usual, which we don’t know on Foundayo.
Outside a 30-day period, if you’ve taken the combined pill correctly, the College of Sexual and Reproductive Healthcare says you won’t need extra contraception when you change to the implant, injection, or either coil in week 2 or 3 of your pack.1112
In the first week after your pill-free break, it advises condoms for 7 days, except with a copper coil. If you’ve had sex without a condom since that break started, ask your clinic before you change.11
If you’re changing from the progestogen-only pill, or to the patch or ring, ask your clinic how long to use condoms.
UKMEC scores how safe a method is, not how well it prevents pregnancy or how it interacts with other medicines, so the progestogen-only pill’s score of 1 doesn’t change the 30-day rule.10
Weight doesn’t appear to change how well most methods work.9 The patch is the exception, as its prescribing information says it may work less well in women weighing 90 kg or more.13
A higher BMI is also linked to a coil coming out.5 Check your threads regularly, and if you can’t feel them, use condoms and contact your clinic, GP, or 111 straight away.
If you stay on the pill and add condoms, use one from the start every time you have sex. The NHS says condoms alone are up to 98% effective if used correctly every time, and 82% if not.
If you use a diaphragm or cap, you may need a different size if you lose or gain more than 3 kg.
Being sick or having diarrhoea on the pill
Foundayo can cause vomiting and diarrhoea.1 If you’re sick soon after taking your pill, or have severe diarrhoea, your body may not absorb enough of the hormones in the pill to prevent pregnancy.4
The table below shows what to do for each type of pill. If you’re sick or have diarrhoea within 30 days of starting Foundayo or increasing your dose, keep using extra contraception until those 30 days end or for as long as the table advises, whichever is later.
| Pill |
Vomiting |
Diarrhoea |
| Combined pill |
Within 3 hours of taking it (4 hours for Qlaira or Zoely): take another pill straight away. If you’re still being sick: use condoms until you’ve taken the pill for 7 days without being sick |
More than 24 hours: keep taking your pill and use condoms until 7 days after it stops |
| Traditional progestogen-only pill |
Within 2 hours of taking it: the pill may not work |
Severe watery diarrhoea: the pill may not work |
| Desogestrel or drospirenone pill |
Within 3 to 4 hours of taking it: the pill may not work |
Severe watery diarrhoea: the pill may not work |
If you take the combined pill and you’re sick or have diarrhoea for more than 24 hours during the last 7 pills before your pill-free break or dummy pills (pills 15 to 21), the NHS says to finish those 7 pills and start your next pack straight away, without a break.
Use condoms until you’ve taken the pill for 7 days without being sick or having diarrhoea. Check your leaflet if your pack has a different pattern, such as Qlaira or Zoely.
The sickness advice can extend beyond a 30-day period. For example, on the combined pill, if you were last sick on day 28 of a 30-day period, you’d keep using condoms until day 35, once you’ve taken the pill for 7 days without being sick.
The NHS doesn’t give one rule for progestogen-only pills, as it depends on how much time has passed and which pill you take.
If your pill may not have worked, you could need emergency contraception. Speak to a pharmacist, sexual health clinic, or GP, or call 111, and ask what to do about your next pills. Your pill’s leaflet also explains this.
Vomiting and diarrhoea are more common while your dose is increasing, which is also when the 30-day periods apply.1
In the two trials reported in the U.S. prescribing information, 13% to 24% of people taking Foundayo vomited, and 21% to 25% had diarrhoea, depending on the dose. Among people taking a placebo, 4% vomited, and 11% had diarrhoea.2
Vomiting and diarrhoea can also cause dehydration, which can harm your kidneys, so drink plenty of fluids. Tell your prescriber if your symptoms are severe, as they may need to lower your dose or stop Foundayo.1
If you keep being sick or having diarrhoea, the College of Sexual and Reproductive Healthcare recommends thinking about switching to a contraceptive you don’t take by mouth, and using condoms every time you have sex.4
Take home message
You can take Foundayo with the contraceptive pill. However, the UK prescribing information advises using extra contraception, such as condoms, for 30 days after you start Foundayo and for 30 days after each dose increase.1
If your dose goes up every 30 days, from the starting dose of 0.8 mg to the highest dose of 17.2 mg, you’d need extra contraception for about 6 months without a break.
No study has tested Foundayo with the pill. A computer model was used to predict how Foundayo would affect the levels of hormones from the pill in our blood, but the same type of model failed to predict the fall in these hormones when Mounjaro was taken with the pill.
Because of this, we recommend using extra contraception for the full 30 days each time, even if you haven’t been sick or had diarrhoea.
Before your first Foundayo tablet, we recommend deciding whether you’ll use condoms throughout these 30-day periods or switch to a contraceptive you don’t take by mouth, such as a coil or implant. Your prescriber or a sexual health clinic can tell you which would suit you.
If you’re sick or have diarrhoea, follow the NHS advice for your type of pill, as you may need to use condoms for more than 30 days.
If you have sex without a condom during a 30-day period, go to a pharmacy or sexual health clinic as soon as you can. Tell them you’re taking Foundayo and which contraceptive pill you take, so they can check whether you need emergency contraception.
Our registered dietitians and nutritionists help members build healthy eating habits so they can maintain their weight loss long term.
A peer-reviewed study in JMIR Formative Research reported that active subscribers on our semaglutide-supported programme lost an average of 19.1% of their body weight at 12 months. Among members with recorded 12-month weights, 77.7% lost at least 10%.14
Second Nature's Mounjaro and Wegovy programmes
Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes.
Why choose Second Nature over other medication providers, assuming you're eligible?
Because peace of mind matters.
We've had the privilege of working with the NHS for over eight years, helping people across the UK take meaningful steps toward a healthier, happier life.
Our programmes are designed to meet people where they are, whether that means support with weight loss through compassionate one-to-one health coaching, or access to the latest weight-loss medications (like Mounjaro and Wegovy) delivered alongside expert care from a multidisciplinary team of doctors, psychologists, dietitians, and personal trainers.
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Frequently asked questions
Will Foundayo stop the pill from working?
We don’t know whether Foundayo makes the pill less effective, as no study has measured this. The prescribing information says it may, and the U.S. prescribing information links this to Foundayo slowing how quickly our stomach empties, which could affect how the pill is absorbed. We don’t know how many people taking both become pregnant.12
Do I need condoms the whole time I’m on Foundayo?
No, if you’re staying on the pill, use condoms for 30 days after starting Foundayo and for 30 days after each dose increase, and for longer if your pill’s sickness advice says so.
The prescribing information also says women who could become pregnant should use effective contraception throughout treatment.1
What if I had sex without a condom during a 30-day period?
Speak to a pharmacist or sexual health clinic about emergency contraception as soon as you can, and tell them you’re taking Foundayo and which pill you take. You have up to 3 days for levonorgestrel, and up to 5 days for ulipristal or a copper coil. Speak to them even if you’re past these limits, as a copper coil can sometimes be fitted later.5 We don’t know the risk of pregnancy, as no one has studied Foundayo with the pill.
Does Foundayo affect Cerazette?
Cerazette is a progestogen-only pill containing desogestrel. We don’t know how Foundayo affects it, as no study or computer simulation has included Cerazette with Foundayo.3
The UK prescribing information for Foundayo advises extra contraception for 30 days after you start Foundayo and after each dose increase, and this includes progestogen-only pills like Cerazette.1
If you’re sick within 3 to 4 hours of taking Cerazette, your body may not have fully absorbed it. Cerazette’s prescribing information says to treat this as a missed pill: take another tablet as soon as you can, then take your next tablet at the usual time.
If you take that tablet more than 12 hours after your usual time, use condoms for the next 7 days.
Does Foundayo affect the contraceptive injection, implant, or coil?
The U.S. prescribing information says Foundayo shouldn’t affect hormonal contraceptives that aren’t taken by mouth, which includes the injection (such as Depo-Provera), the implant, and the hormonal coil.2 The UK prescribing information doesn’t say this directly, but its advice only covers oral contraceptives.1
The copper coil doesn’t use hormones, and the College of Sexual and Reproductive Healthcare says it isn’t known to be affected by other medicines.5
Can I skip extra contraception if I take the pill and Foundayo at different times?
No. The prescribing information gives no advice to separate them, and no Foundayo study has shown that it helps.1
You can take Foundayo at any time of day,1 so we recommend taking your pill at your usual time and using extra contraception.
Do I need extra contraception if my dose goes down?
No, a lower dose doesn’t start a new 30-day period, as the prescribing information only mentions starting Foundayo and dose increases.1 Finish any 30-day period you’ve already started.
Our inference is that returning to a higher dose counts as a dose increase, so we recommend 30 days of extra contraception.
What if I restart Foundayo after a break?
The prescribing information says that if you miss a dose, you should take it as soon as possible, without taking more than one tablet a day. It doesn’t cover restarting after a longer break, or say how long that is.1
Our inference from the wording is that a restart counts as a new start, so we’d recommend extra contraception for 30 days from your first tablet back. Ask your prescriber whether your break counts as a restart, and which dose to take.
Does the 30-day rule apply if I switch from Mounjaro or Wegovy?
The MHRA hasn’t commented on switching. We can infer that the 30 days apply from your first Foundayo tablet, because the prescribing information counts from when you start Foundayo.
Foundayo is a different medicine, so how well your pill worked while you were taking Mounjaro or Wegovy doesn’t tell us how well it will work with Foundayo.
Did the Foundayo trials show the pill still works?
No. In ATTAIN-1, the main Foundayo weight-loss trial, women who could become pregnant had to use 2 forms of contraception, so the trial can’t show how well the pill works alone.15
How long before pregnancy should I stop Foundayo?
Stop Foundayo at least 3 weeks before a planned pregnancy, compared with at least 1 month for Mounjaro and 2 months for Wegovy and the Wegovy pill.146
The wait is there because Foundayo takes time to leave the body, so keep using contraception during those 3 weeks.1
Foundayo shouldn’t be used during pregnancy or breastfeeding. If you become pregnant, stop taking it and speak to your prescriber.1
Why can’t I take Foundayo during pregnancy?
There are no good-quality studies of Foundayo in pregnant women, and studies in animals have shown harm to reproduction.1
In the trials, 14 pregnancies were reported in women who had taken Foundayo, not all of whom were still taking it. The FDA said this was too little information to draw conclusions, so Foundayo’s safety in pregnancy is largely unknown.3