Second Nature vs Bolt Pharmacy

Jump to: At-a-glance comparison | Core approach differences | Clinical credibility & NHS partnership | Programme structure | Support & coaching | Pricing & accessibility | Long-term outcomes | Take home message

This article is accurate to the best of our knowledge as of December 2025.

When choosing between Second Nature and Bolt Pharmacy for medication-supported weight loss, the most important difference is whether you want medication alone or medication combined with support for lasting change.

At Second Nature, we’ve been delivering NHS-commissioned weight-loss services since 2017, combining medication with habit-change support from registered dietitians and nutritionists.

Bolt Pharmacy positions itself as a transparent, low-cost medication provider, offering GLP-1 injections at competitive ‘no markup’ prices with basic clinical oversight but no structured behavioural programme.

Both services provide access to effective weight-loss medications, but they represent fundamentally different approaches to weight management.

The most significant differences between these programmes are:

• Core approach: At Second Nature, we build sustainable habits through behavioural psychology alongside medication, while Bolt Pharmacy focuses on affordable medication access with self-managed weight loss
• Clinical support: We provide registered dietitians and nutritionists five days a week, while Bolt offers clinician check-ins and written guides
• NHS partnership: We’ve been delivering NHS-commissioned services since 2017 with peer-reviewed outcomes, while Bolt operates as a private GPhC-registered pharmacy
• Long-term planning: We focus on sustainable habit formation for life after medication, while Bolt’s approach centres on medication provision

This guide will help you understand which approach aligns better with your health goals, preferences, and budget.

Second Nature vs Bolt Pharmacy: At-a-glance comparison

Core approach differences

Second Nature: Habit change alongside medication

At Second Nature, we view medication as one part of a comprehensive approach to weight management.

Our programme is built on behavioural science developed through years of NHS collaboration. We help you understand the complex interplay between biology, psychology, and environment that influences eating patterns and weight.

Research consistently shows that people who stop GLP-1 medications without developing sustainable habits typically regain around two-thirds of their lost weight within a year.¹

Our approach addresses this by building habits from day 1, so you’re prepared for life after medication.

Bolt Pharmacy: Affordable medication access

Bolt Pharmacy operates with a clear mission: making prescription weight-loss treatments accessible at transparent, competitive prices.

Their ‘no markup’ pricing model shows exactly how they calculate costs, breaking down the manufacturer price, medical professional fees, running costs, shipping, and profit margin.

This approach works well for people who already understand nutrition and behaviour change, or who have external support systems in place.

Bolt emphasises that they believe ‘life-changing medications should be accessible to everyone, and no one should be priced out of the care they need.’

Clinical credibility & NHS partnership

Second Nature: NHS-trusted approach

Since 2017, the NHS has commissioned us to deliver weight loss and type 2 diabetes programmes across the UK, with over half of UK NHS Health Boards now using our services.

This partnership reflects the confidence healthcare professionals place in our behaviour-change approach.

Our effectiveness is supported by peer-reviewed research. Our 2025 study, published in JMIR Formative Research, examined 12-month outcomes with semaglutide combined with behavioural support:

• 19.1% average weight loss for participants who maintained an active subscription
• 77.7% achieved ≥10% weight loss at 12 months
• 61.5% achieved ≥15% weight loss at 12 months
• 69% reported no side effects by month 12 with proper support²

Bolt Pharmacy: Regulated medication provider

Bolt Pharmacy is a GPhC-registered pharmacy (registration number 9012625), ensuring all medications are legitimate and properly dispensed.

Their clinicians are UK-registered prescribers who conduct medical assessments before approving treatment.

For weight-loss outcomes, Bolt cites clinical trial data for the medications it supplies rather than programme-specific evidence. They cite Mounjaro’s average weight loss of 22.5% in clinical trials.

While Bolt publishes informational guides on topics such as managing side effects and comparing GLP-1 medications, there’s no published research examining outcomes specific to its service model.

Programme structure & philosophy

Second Nature: Building sustainable habits alongside medication

Our programme recognises that lasting weight loss requires more than medication alone.

Rather than focusing solely on medication effects, we help you understand why you eat the way you do and how to build habits that support your health long-term.

Our approach includes:

• Building sustainable habits that work with your unique body and lifestyle
• A non-restrictive nutrition philosophy that doesn’t require calorie counting
• Structured educational content based on clinical evidence
• An intuitive app with food journals, 300+ recipes, and progress tracking
• Supportive peer groups with others on similar journeys
• Specific protocols for managing side effects and transitioning off medication

We view medication as a tool that creates a window of opportunity to develop habits while appetite is reduced and food noise is quieter.

Bolt Pharmacy: Streamlined medication access

Bolt Pharmacy offers a straightforward process:

• Complete an online consultation form
• Clinicians review and approve if suitable
• Medication dispatched with cold-chain delivery, often next day
• Monthly check-ins via their website
• Access to written guides on nutrition and side effect management
• 5% weight loss guarantee within 6 months or money back

Their approach is designed for people who want efficient access to medication without an extensive programme structure.

Bolt has developed their website to include check-in functionality and provides a comprehensive booklet with medication orders, though this represents basic support rather than a structured behaviour-change programme.

Support & coaching

Second Nature: Professional guidance and peer support

We provide access to UK-registered dietitians and nutritionists who specialise in supporting people on weight-loss medications.

These qualified professionals are available five days a week via both group and private chat as part of your standard programme cost.

Our health coaches receive specific training in GLP-1 medication management, helping you navigate:

• Side effects like nausea, constipation, and fatigue
• Adjusting eating patterns as appetite changes
• Building protein-focused meals to maintain muscle mass
• Strategies for managing hunger when medication effects fluctuate
• Preparation for eventually stopping medication

We place you in a small group with others on similar journeys, creating a supportive community where you can share experiences and strategies.

Bolt Pharmacy: Basic clinical support

Bolt Pharmacy provides:

• Online consultation with UK-registered clinicians
• Monthly check-ins via their website
• Written guides on nutrition and side effect management
• Responsive customer service via WhatsApp and email
• Clinician messaging for medication-related queries

Customer reviews praise Bolt’s responsive communication and customer service. Their team actively responds to queries and resolves issues promptly.

However, their support focuses on medication management rather than comprehensive lifestyle coaching. There are no registered dietitians, nutritionists, or peer support groups.

This approach relies on self-management and works well for motivated individuals who are confident in making their own dietary and lifestyle changes.

Pricing & accessibility

Comprehensive pricing overview

Second Nature with Mounjaro:

• First month: £179
• Subsequent months: up to £349 depending on dose
• All-inclusive: medication, delivery, app access, dietitian support, peer groups

Second Nature with Wegovy:

• First month: £99
• Subsequent months: up to £249 depending on dose
• All-inclusive: medication, delivery, app access, dietitian support, peer groups

Bolt Pharmacy Mounjaro pricing:

• 2.5 mg and 5 mg: £149 per pen
• 7.5 mg and 10 mg: £179 per pen
• 12.5 mg and 15 mg: £199 per pen
• First month promotional discount: £29 off
• Financial assistance is available for people receiving certain benefits

Bolt Pharmacy Wegovy pricing:

• From £23/week (approximately £92-100 monthly at lower doses)
• Prices increase with higher doses

Value comparison

Bolt Pharmacy’s per-pen pricing is lower, but this reflects what’s included:

Second Nature includes:

• Medication costs and delivery
• Full access to the app with 300+ recipes
• Support from registered dietitians and nutritionists
• Placement in peer support groups
• Educational content and habit-forming tools
• Post-medication transition planning

Bolt Pharmacy includes:

• Medication at transparent ‘no markup’ pricing
• Cold-chain overnight delivery
• Clinical oversight and monthly check-ins
• Written guides and informational resources
• 5% weight loss guarantee or money back

For people who primarily need affordable access to medication and are confident in managing their own lifestyle changes, Bolt offers genuine value.

For those wanting comprehensive support to build lasting habits, Second Nature’s all-inclusive pricing may represent better long-term value.

Long-term outcomes

Second Nature: Building for lasting results

Our approach focuses on what happens after medication, not just during treatment.

Our 2025 JMIR study showed that participants who completed our behaviour-change programme alongside medication achieved significantly better outcomes:

• 19.1% average weight loss at 12 months
• 77.7% achieved clinically significant weight loss (≥10%)
• Only 3.2% weight regain at five months after stopping for those who developed sustainable habits

We acknowledge that dramatic weight loss makes compelling marketing, but sustainable change requires addressing the underlying habits and psychology around food.

Bolt Pharmacy: Medication-focused outcomes

Bolt Pharmacy emphasises:

• Transparent pricing enabling longer treatment periods
• References clinical trial outcomes (e.g., Mounjaro’s 22.5% weight loss)
• 5% weight loss guarantee within 6 months
• Customer reviews praising service efficiency and value

Their outcomes primarily reflect medication effectiveness. Success after stopping medication depends largely on individual self-management capabilities.

Bolt’s customer reviews are overwhelmingly positive, with consistent praise for competitive pricing, fast delivery, and responsive customer service.

Their 4.4/5 Trustpilot rating, based on 700+ reviews, reflects customer satisfaction with the medication provision model.

Take home message

Weight-loss medications like Mounjaro and Wegovy can support significant weight loss when used appropriately. The key question is whether you want medication alone or medication combined with comprehensive support for lasting change.

Your choice between Second Nature and Bolt Pharmacy should reflect your personal health philosophy, support preferences, and budget.

Choose Second Nature if you value:

• Evidence-based approach with NHS partnership and peer-reviewed outcomes
• Comprehensive support from UK-registered dietitians
• Sustainable philosophy focused on habits that last beyond medication
• Community support from peer groups and ongoing professional guidance
• Post-medication planning with strategies for maintaining results
• Psychology-based understanding of eating behaviours

Choose Bolt Pharmacy if you value:

• Transparent, competitive pricing with ‘no markup’ model
• Self-management with confidence in your own dietary knowledge
• Simplicity with streamlined medication access
• Speed with fast delivery and efficient processes
• Financial accessibility, including support for those on certain benefits
• Flexibility without long-term programme commitments

At Second Nature, we believe sustainable weight management continues long after medication ends.

Our programme teaches you to build a healthier relationship with food by understanding habits rather than relying on medication.

If you’ve struggled with weight regain after previous attempts and want comprehensive support for lasting change, our NHS-validated approach provides the foundation for sustainable success.

If you’re confident in managing your weight loss and primarily need affordable, reliable access to medication, Bolt Pharmacy offers a transparent, well-reviewed service.

Remember that the ultimate goal isn’t just weight loss, but maintaining your results and building a healthier relationship with food for life.

Frequently asked questions

Is Bolt Pharmacy legitimate?

Yes. Bolt Pharmacy is GPhC-registered (number 9012625) and uses UK-registered prescribers. They’re a legitimate online pharmacy with transparent pricing and positive customer reviews.

Which is cheaper: Second Nature or Bolt Pharmacy?

Bolt Pharmacy’s per-pen Mounjaro pricing (£149-£199) is lower than Second Nature’s monthly cost (£179-349).

However, Second Nature offers comprehensive support, including dietitians, an app, peer groups, and post-medication planning. The better value depends on whether you need that support.

Does Bolt Pharmacy offer Wegovy?

Yes. Bolt Pharmacy offers both Wegovy and Mounjaro. Second Nature also offers both medications.

What support does Bolt Pharmacy provide?

Bolt provides clinical consultations, monthly check-ins via their website, written guides, and responsive customer service. They don’t offer registered dietitians, nutritionists, or peer support groups.

How do I maintain weight loss after stopping medication?

Research shows that developing sustainable habits while on medication is key to maintaining results.

Without behavioural support, around two-thirds of weight is typically regained within a year of stopping.

Second Nature’s programme specifically addresses this; Bolt Pharmacy’s approach relies on self-management.

Does Bolt Pharmacy have a money-back guarantee?

Yes. Bolt offers a full refund if you don’t achieve at least 5% body weight reduction within 6 months of following their plan.

Second Nature’s medication programmes

Second Nature has two medication-supported programmes: a Wegovy weight-loss programme and a Mounjaro weight-loss programme.

Why should you choose Second Nature over other medication providers if you’ve decided to try Mounjaro or Wegovy (assuming you’re eligible)?

For peace of mind.

Second Nature has worked with the NHS for over 6 years, providing weight-loss programmes across the UK.

While our Wegovy and Mounjaro weight-loss programmes are private and not currently used by the NHS, we’ve built the programmes focusing on scientific evidence, patient safety, and data security.

We hope that our 6+ years of working with the NHS and building a track record of effective weight-loss results will give you peace of mind to give us a try.

References

1. Wilding JPH, et al. (2022). Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity and Metabolism.
2. Richards R, et al. (2025). A Remotely Delivered, Semaglutide-Supported Weight Management Program: 12-Month Outcomes From a Retrospective Service Evaluation. JMIR Formative Research.