US
Weight-loss medications
Evidence-based guidance on weight-loss medications including GLP-1 receptor agonists like Wegovy, Ozempic, and Mounjaro. Find reliable information on efficacy, side effects, NHS availability, and how these medications work as part of a balanced approach to weight loss. Our content is developed by healthcare professionals and nutritionists to support informed decisions about medication-assisted weight loss in the UK.
Weight-loss medications
Retatrutide vs Wegovy: which works better for weight loss?
Retatrutide produced 28.7% weight loss in trials vs Wegovy 7.2 mg's 20.7%. Retatrutide isn't UK-approved yet; Wegovy is the current option.
Weight-loss medications
Retatrutide side effects: what the trials show and how to manage them
Retatrutide's main side effects in trials: nausea (43%), heart rate increase of ~6.7 bpm, and dysesthesia (20.9%) at the 12 mg dose. Not yet UK-approved.
Weight-loss medications
Retatrutide vs Mounjaro
In trials, retatrutide reached 28.7% weight loss vs Mounjaro's 22.5%. Retatrutide isn't UK-approved yet, so Mounjaro is the current option.
Weight-loss medications
CagriSema vs Mounjaro: how they compare on weight loss, side effects, and UK availability
Mounjaro produced more weight loss than CagriSema in REDEFINE 4: 25.5% vs 23.0% over 84 weeks. Only Mounjaro is licensed and available in the UK.
Weight-loss medications
What is CagriSema? A UK guide to Novo Nordisk’s new weight-loss injection
CagriSema: 22.7% weight loss in REDEFINE 1, the highest for any Novo Nordisk obesity drug. Lost head-to-head to Mounjaro. Not yet UK-approved.
Weight-loss medications
When will CagriSema be available in the UK?
CagriSema isn't yet available in the UK. No MHRA filing as of May 2026. Private launch likely 2026-2027, NHS access from 2028.
Wegovy compatibility
Can you take Wegovy with rheumatoid arthritis?
You can take Wegovy with rheumatoid arthritis. Find out how it interacts with RA medications and why weight loss may improve disease activity.
Wegovy compatibility
Can you take Wegovy if you have chronic kidney disease (CKD)?
You can take Wegovy with chronic kidney disease. Find out which stages are safe, how to monitor, and why it may protect kidney function.
Wegovy compatibility
Can you take Wegovy after a gastric band?
You can take Wegovy after a gastric band, but the combination needs medical supervision. Find out what to expect from your bariatric team and GP.
Wegovy compatibility
Can you take Wegovy with fibromyalgia?
Wegovy is safe to take with fibromyalgia. What the evidence shows on weight loss, pain, and fatigue, plus practical guidance for managing both.
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