Second Nature logo

US

Interested in our medication-supported weight-loss programme?

Weight-loss medications

Evidence-based guidance on weight-loss medications including GLP-1 receptor agonists like Wegovy, Ozempic, and Mounjaro. Find reliable information on efficacy, side effects, NHS availability, and how these medications work as part of a balanced approach to weight loss. Our content is developed by healthcare professionals and nutritionists to support informed decisions about medication-assisted weight loss in the UK.
Does Wegovy help you drink less alcohol?

Weight-loss medications

Does Wegovy help you drink less alcohol?

Wegovy appears to reduce how much alcohol people drink. How it affects cravings and hangovers, and what drinking safely on it looks like.

Foundayo (orforglipron): what it is, how it works, and when it’s coming to the UK

Weight-loss medications

Foundayo (orforglipron): what it is, how it works, and when it’s coming to the UK

Foundayo (orforglipron) is a daily GLP-1 pill for weight loss (11.2%) with no fasting requirements. MHRA approved for UK use on August 10th 2026.

Can oral weight-loss medications help you maintain weight loss after Mounjaro or Wegovy?

Weight-loss medications

Can oral weight-loss medications help you maintain weight loss after Mounjaro or Wegovy?

ATTAIN-MAINTAIN trial: people who switched from Mounjaro or Wegovy injections to Foundayo kept 75-79% of their weight loss. Now approved in the UK.

Wegovy and tingling hands: the dysaesthesia side effect explained

Weight-loss medications

Wegovy and tingling hands: the dysaesthesia side effect explained

Tingling on Wegovy affected 22.9% of people on 7.2 mg and 6.0% on 2.4 mg in the STEP UP trial. Why it happens, and when to speak to your prescriber.

Can you get Ozempic on the NHS?

Weight-loss medications

Can you get Ozempic on the NHS?

Ozempic is only available on the NHS for type 2 diabetes, not weight loss. Wegovy and Mounjaro are the UK's licensed weight-loss injections.

Can you get the Wegovy pill on the NHS?

Weight-loss medications

Can you get the Wegovy pill on the NHS?

You can't get the Wegovy pill on the NHS yet. It's UK-approved, but NHS funding needs a NICE decision, most likely in 2028.

Am I on track? A free GLP-1 weight-loss progress checker

Weight-loss medications

Am I on track? A free GLP-1 weight-loss progress checker

Use our free GLP-1 progress checker to see if you're on track with your weight loss and habits while taking Mounjaro, Wegovy, or the Wegovy pill.

Can I take the Wegovy pill with levothyroxine?

Weight-loss medications

Can I take the Wegovy pill with levothyroxine?

You can take the Wegovy pill with levothyroxine, but not together. Take the pill, wait 30 minutes, then levothyroxine, or move it to bedtime.

Should I switch to the Wegovy pill from Wegovy or Mounjaro injections?

Weight-loss medications

Should I switch to the Wegovy pill from Wegovy or Mounjaro injections?

The Wegovy pill, oral semaglutide, produces around 13.6% average weight loss, similar to the 2.4 mg injection but less than Mounjaro or the 7.2 mg dose.

Mounjaro alternatives: Your complete guide to weight loss options in 2026

Weight-loss medications

Mounjaro alternatives: Your complete guide to weight loss options in 2026

Mounjaro alternatives UK: Compare Wegovy, the Wegovy pill, Saxenda, and Orlistat. Includes clinical trial data, side effects, and pricing.

Make losing weight feel Second Nature

The first step on your Second Nature journey is to take our health quiz.

Hand holding phone

As seen on

The GuardianThe TimesChannel 4The Sunday TelegraphEvening StandardMetro