Weight-loss medications
Evidence-based guidance on weight-loss medications including GLP-1 receptor agonists like Wegovy, Ozempic, and Mounjaro. Find reliable information on efficacy, side effects, NHS availability, and how these medications work as part of a balanced approach to weight loss. Our content is developed by healthcare professionals and nutritionists to support informed decisions about medication-assisted weight loss in the UK.
Weight-loss medications
Foundayo vs Rybelsus: which tablet is right for you?
Foundayo vs Rybelsus: 9.2% vs 5.3% average weight loss over 52 weeks in a type 2 diabetes trial. Compare side effects and UK prescribing.
Weight-loss medications
Does Foundayo make you feel tired?
Foundayo can make you feel tired. Learn how appetite changes, dehydration, and brain effects may contribute, plus practical ways to improve your energy.
Weight-loss medications
Why am I not losing weight on Foundayo?
You might not be losing weight on Foundayo because the dose isn't lowering hunger enough, you've reached a plateau, or your eating habits haven't changed.
Weight-loss medications
Foundayo (orforglipron): what it is, how it works, and when it’s coming to the UK
Foundayo (orforglipron) is a daily GLP-1 pill for weight loss (11.2%) with no fasting requirements. MHRA approved for UK use on August 10th 2026.
Weight-loss medications
Foundayo vs Wegovy injection: which is better for weight loss?
Wegovy leads to more weight loss than Foundayo on average, but some people may prefer a daily tablet over weekly injections. Read how they compare.
Weight-loss medications
Should you stop Wegovy or Mounjaro before surgery?
Current UK guidance says to continue Wegovy or Mounjaro before surgery. See what the GLIMPSE study found and what to tell your anaesthetist.
Weight-loss medications
GLP-1 drugs and brain disorders: what does the evidence show?
GLP-1 medicines haven't been shown to cause brain damage. Learn what Wernicke reports reveal about thiamine deficiency and eating habits.
Weight-loss medications
Can you take Foundayo with antidepressants?
Most prescribed antidepressants can usually be taken with Foundayo. Learn about interactions, side effects, and when to contact your prescriber.
Weight-loss medications
Can you take Foundayo if you have epilepsy?
Foundayo (orforglipron) may be suitable if you have epilepsy, but it shouldn't be used with carbamazepine or phenytoin. Find out more here.
Weight-loss medications
Can you take Foundayo after breast cancer?
You can take Foundayo after having breast cancer, as long as you're no longer receiving active treatment and are in complete remission. Find out more here.
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