Jump to: Why choose Second Nature’s medication programmes | Our medication-supported programmes | Not a magic pill – building habits for life | How it works | Safety and side effect management | Our NHS heritage | The story behind our medication programmes | Frequently asked questions
Second Nature combines prescription weight-loss medications (Mounjaro and Wegovy) with expert habit-change support from registered dietitians and nutritionists.
Our approach helps you lose 18-22% of your body weight while building sustainable habits for long-term weight loss maintenance.
Important safety information: Mounjaro (tirzepatide) and Wegovy (semaglutide) are prescription-only medications for treating type 2 diabetes and managing obesity. This article is for informational purposes only. Always consult with your healthcare provider before starting any new medication, particularly if you have had your gallbladder removed or have other health conditions.
Why choose Second Nature’s medication programmes
Recent research published in JMIR Formative Research (2025) showed that Second Nature participants achieved an average of 18-22% weight loss at 12 months1, similar to the weight loss achieved in clinical trials2. The difference is our comprehensive habit-change support alongside medication.
What makes us different:
- 6+ years NHS experience – We’ve delivered weight-loss services to over 250,000 NHS patients since 2017
- Registered healthcare professionals – Get support 5 days a week from UK-registered dietitians and nutritionists
- Proven results – NHS England published our outcomes in the British Medical Journal showing 6.2kg average weight loss at 12 months on our non-medication programme3
- Guaranteed medication supply – We cap weekly enrolments to ensure consistent access
- Comprehensive programme – Medication plus behavioural psychology, nutrition education, and lifestyle coaching
Our medication-supported programmes
Mounjaro Programme
- Weight loss potential: 20-25% of body weight4
- Monthly cost: Costs to be confirmed in October (including medication, coaching, and app)
- How it works: Tirzepatide mimics two hormones (GLP-1 and GIP) to reduce appetite and improve blood sugar control
Wegovy Programme
- Weight loss potential: 15-20% of body weight2
- Monthly cost: £149-£249, depending on the dose (£50 off first month)
- How it works: Semaglutide mimics GLP-1 hormone to reduce hunger and increase feelings of fullness
Both programmes include:
- Prescription medication delivered monthly
- Smart weighing scales and a hardback recipe book
- Daily habit-change content through our award-winning app
- Personal health coach (registered dietitian/nutritionist)
- Peer support groups
Not a magic pill – building habits for life
Weight-loss medications are effective at reducing appetite, but research shows that without lifestyle changes, weight regain is common after stopping medication5.
That’s where Second Nature comes in. While the medication helps kickstart your weight loss, our programme focuses on:
- Building sustainable eating habits
- Understanding your relationship with food
- Creating routines that support long-term health
- Managing the psychological aspects of weight loss
- Preparing for life after medication
Our approach means that when you’re ready to stop medication, you have the skills and habits to maintain your weight for life.
How it works
Step 1: Clinical assessment
Our pharmacists review your health information to ensure medication safety and that you’re eligible for the programme.
Step 2: Welcome package delivery
Receive your first month’s medication (if eligible), smart scales, recipe book, and programme materials discreetly delivered.
Step 3: Daily habit building
Spend just 5-10 minutes daily with science-based articles, track your progress, and get support from your health coach.
Step 4: Sustainable results
Alongside significant weight loss, our members report improved mood, sleep, energy levels, and confidence.
Safety and side effect management
While most people experience only mild side effects that ease as your body adapts, our team provides comprehensive support:
- Health coaches trained in GLP-1 side effect management
- 24/7 access to side effect guidance through the app
- Direct pharmacist support when needed
- Personalised strategies for managing nausea, constipation, or fatigue
Our NHS heritage and clinical partnerships
Second Nature has partnered with the NHS since 2017, delivering:
- NHS Diabetes Prevention Programme
- Specialist weight management services
- Type 2 diabetes remission programmes
We’ve also partnered with Vitality Health to support the health goals of their 1.7 million members.
While our Mounjaro and Wegovy programmes are private services, they’re built on the same evidence-based foundation and clinical governance that the NHS trusts.
The story behind our medication programmes
In 2023, when groundbreaking GLP-1 medications became available in the UK, we recognised an opportunity to enhance our proven habit-change programmes. The clinical trial data revealed significant potential; but we also saw that medication alone wasn’t the complete answer.
Our years of NHS experience taught us that sustainable weight loss requires addressing both the biological and behavioural aspects of obesity.
By combining medication with our established coaching methodology, we created programmes that deliver superior, lasting results.
Frequently asked questions
What are GLP-1 medications
GLP-1 receptor agonists are injectable medications that mimic hormones your body naturally produces after eating. They work by:
- Slowing stomach emptying to increase fullness
- Reducing appetite signals in the brain
- Improving blood sugar control
- Supporting sustainable weight loss
How much weight will I lose
Based on our 2025 research, participants maintaining their programme achieved ~18-22% average weight loss at 12 months1. Individual results vary based on starting weight, medication response, and habit changes.
Are side effects common
Most people experience mild side effects initially (nausea, constipation, fatigue) that improve within weeks. By month 12, 69% of our participants reported no side effects1.
Can I do Second Nature without medication
Yes. Our original behaviour-change programme remains available without medication, trusted by over 250,000 people to date.
How long do I need to take medication
Treatment duration is individualised. Most participants use medication for 6-12 months while establishing sustainable habits, though some choose longer treatment. Our coaches help plan your transition when ready.
What happens when I stop the medication
Our programme specifically prepares you for medication cessation through habit formation and psychological support. While some weight regain is possible, our approach minimises this through sustainable lifestyle changes.
How much does it cost
- Mounjaro: Costs to be confirmed in October
- Wegovy: £149-£249 a month depending on the dose (£50 off first month)
- Non-medication programme: £38 a month
All medication programmes include coaching, app access, and clinical support.
Why choose Second Nature over other providers
With 6+ years of NHS partnership, published clinical outcomes, and comprehensive behavioural support, we offer evidence-based weight loss that lasts. Our registered dietitians and proven methodology set us apart from medication-only providers.
Ready to start your journey
Join thousands who’ve transformed their health with Second Nature’s medication programmes. Our clinical team will assess your eligibility and recommend the most suitable approach for your goals.
Second Nature's Mounjaro and Wegovy programmes
Second Nature provides Mounjaro or Wegovy as part of our Mounjaro and Wegovy weight-loss programmes.
Why choose Second Nature over other medication providers, assuming you're eligible?
Because peace of mind matters.
We've had the privilege of working with the NHS for over eight years, helping people across the UK take meaningful steps toward a healthier, happier life.
Our programmes are designed to meet people where they are, whether that means support with weight loss through compassionate one-to-one health coaching, or access to the latest weight-loss medications (like Mounjaro and Wegovy) delivered alongside expert care from a multidisciplinary team of doctors, psychologists, dietitians, and personal trainers.
At the heart of everything we do is a simple belief: real, lasting change comes from building better habits, not relying on quick fixes. We're here to support that change every step of the way.
With over a decade of experience, thousands of lives changed, and a long-standing record of delivering programmes used by the NHS, we believe we're the UK's most trusted weight-loss programme.
We hope to offer you something invaluable: peace of mind, and the support you need to take that first step.
References:
- Richards, R., Lunt, W., Whitman, M., Spaltro, G., & Hall, R. (2025). Semaglutide and Tirzepatide in a Remote Weight Management Program: 12-Month Retrospective Observational Study. JMIR Formative Research, 9(1), e81912.
- Wilding JPH, et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 384:989-1002.
- NHS England. (2024). National Diabetes Prevention Programme: Weight Loss and HbA1c Outcomes. BMJ Open.
- Jastreboff AM, et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 387:205-216.
- Wilding JPH, et al. (2022). Weight regain after withdrawal of semaglutide. Diabetes Obes Metab. 24:1553-1564.
