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How Wegovy works
Wegovy is the injectable form of semaglutide, a GLP-1 medicine taken as a once-weekly injection under the skin. There is now also a Wegovy pill, the same medicine taken as a daily tablet.
It mimics GLP-1 and works through three routes: it acts on the appetite centres in the brain to lower hunger, slows the stomach so we feel fuller for longer after meals, and prompts the pancreas to release insulin to help manage blood sugar. The result is naturally eating less without battling cravings.
How you take it
A once-a-week injection, taken on any day, at any time, with or without food. You start low and step up, beginning at 0.25 mg and increasing roughly every four weeks to the 2.4 mg maintenance dose, which takes around 16 weeks.
There is also a higher 7.2 mg dose, approved in January 2026, taken as the same weekly injection and built up over around 28 weeks.
Results to expect
Wegovy works for most people. On the 2.4 mg dose, people lost around 15% of their body weight over 68 weeks, and around 69% lost more than 10%. The higher 7.2 mg dose reached around 20.7% over 72 weeks. Results come fairly quickly and then level off, with most of the loss in the first 32 weeks.
Medication does much of the heavy lifting, but the habits you build alongside it are what keep the weight off.
Side effects and safety
The most common side effects are gut-related, such as nausea, diarrhoea and constipation, and are usually worst early on before easing as the body adjusts. In trials of the 2.4 mg injection, around 44% of people had nausea and 30% had diarrhoea. Building the dose up gradually keeps these as mild as possible.
Like other GLP-1 medicines, it carries a warning about a rare type of thyroid tumour, based on animal studies, so it is not recommended for anyone with a personal or family history of medullary thyroid cancer. A clinician always checks it is right for you, and reviews your history, before you start.
Who it is for
Wegovy is a prescription-only medicine, so your suitability is checked before you start. It is generally for adults with a BMI of 30 or above, or 27 to 30 with a weight-related condition such as type 2 diabetes or high blood pressure.
Everyone goes through a clinical eligibility check first.
What you get with Second Nature
The injection is not meant to be forever, and stopping suddenly is where people come unstuck: in trials, people regained about two-thirds of the weight they had lost within a year of stopping. That is the gap our programme is built to close.
Our research found that 59% of people who reduced their dose slowly while building healthy habits kept their weight off six months later. Your plan wraps the injection in real change: a registered dietitian, daily coaching in the app, and a structured approach to food, movement and sleep.
Frequently asked questions
Should I get the Wegovy injection or the pill?
Both are semaglutide, just a different format. The injection is a weekly jab you can take at any time, while the pill is a daily tablet taken on an empty stomach with a 30-minute wait. Weight loss is broadly similar, with the injection edging it slightly.
How often do I inject Wegovy?
Once a week, on any day. You start at 0.25 mg and step up roughly every four weeks to the 2.4 mg maintenance dose.
How much weight can I lose on Wegovy?
On the 2.4 mg dose, people lost around 15% of their body weight over 68 weeks, and around 69% lost more than 10%. The higher 7.2 mg dose reached around 20.7% over 72 weeks.
How quickly does Wegovy work?
Results come fairly quickly and then level off, with around 5% lost by one month and 8% by two months. Most of the weight loss happens in the first 32 weeks.
Will I regain the weight if I stop?
If you stop suddenly, people regained about two-thirds of their lost weight within a year. Our research found that 59% of people who reduced their dose slowly while building healthy habits kept their weight off six months later.
What are the side effects of Wegovy?
Mostly gut-related, such as nausea, diarrhoea and constipation, and worst early on before easing. Around 44% had nausea in trials of the 2.4 mg dose, and a clinician checks your suitability first.
Should I choose Wegovy or Mounjaro?
At standard maximum doses, Mounjaro produced around 20% weight loss versus around 14% for Wegovy. Mounjaro works on two appetite hormones and Wegovy on one, and a clinician helps you decide which suits you.
Sources
Wegovy 2.4 mg weight loss (around 15% over 68 weeks; around 69% lost more than 10%): STEP 1 trial of semaglutide 2.4 mg.
Wharton S, Freitas P, Hjelmesæth J, et al; STEP UP Trial Group. Once-weekly semaglutide 7.2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial. Lancet Diabetes Endocrinol. 2025;13(11):949-963. doi:10.1016/S2213-8587(25)00226-8
Weight regain after stopping (around two-thirds within a year): STEP 1 trial extension. Second Nature taper outcome (59% kept weight off at six months): internal member data.
Wegovy versus Mounjaro (around 14% vs around 20%): SURMOUNT-5 head-to-head trial.
What you'll get
Here’s everything that’s included in the cost of your monthly plan
Enjoy 100+ nutritious recipes and bluetooth scales with your first order.
Monthly
The Complete Programme
All accessible via the app12-month guided programme
Think of it like a masters for your health. A structured programme proven to build lasting habits and sustainable weight loss.
A dedicated nutritionist
Get a consultation and ongoing support from a dedicated nutritionist who will monitor your side effects and give you tailored health advice.
Monthly clinical reviews
Get ongoing clinical reviews, dose optimisation and a tailored plan to maintain and come off the medication when you're ready.
Exclusive member community
Join a close knit support group that shares your worries, wins and journey. You don't need to feel alone anymore.
Second Nature App (4.8★)
Our top rated app, used by the NHS allows you learn, track habits, plan meals and monitor your progress. You'll have free access for life.
12-month guided programme
Think of it like a masters for your health. A structured programme proven to build lasting habits and sustainable weight loss.
A dedicated nutritionist
Get a consultation and ongoing support from a dedicated nutritionist who will monitor your side effects and give you tailored health advice.
Monthly clinical reviews
Get ongoing clinical reviews, dose optimisation and a tailored plan to maintain and come off the medication when you're ready.
Exclusive member community
Join a close knit support group that shares your worries, wins and journey. You don't need to feel alone anymore.
Second Nature App (4.8★)
Our top rated app, used by the NHS allows you learn, track habits, plan meals and monitor your progress. You'll have free access for life.
Health team in your pocket
The medication alone is not enough, we offer comprehensive human support so you're never left feeling stuck or alone.
Clinical oversight
Your clinician reviews your progress and plan each month.
1-1 health coaching
Get personalised guidance on side effects and nutrition.
Customer support
Our team is here to help with any technical issues or concerns.
Peer community
Connect with others on a similar journey to you.
Clinical oversight
Your clinician reviews your progress and plan each month.
1-1 health coaching
Get personalised guidance on side effects and nutrition.
Customer support
Our team is here to help with any technical issues or concerns.
Peer community
Connect with others on a similar journey to you.
You don't need to figure it out alone anymore
Our team of doctors, psychologists, and dietitians guide your journey
The Second Nature App
Designed by psychologists.
Recommended by GPs. Used by the NHS.
4.8
out of 5
6.2K Ratings
Break old habits and thought patterns to build lasting healthy habits
Handy tools and resources to support a healthy lifestyle and mindset
Improve your relationship with food. No deprivation or obsessive thoughts
Celebrate your progress. Track habits, weight, steps and sleep improvements
The Second Nature App
Designed by psychologists.
Recommended by GPs. Used by the NHS.
4.8
out of 5
6.2K Ratings
Break old habits and thought patterns to build lasting healthy habits
Handy tools and resources to support a healthy lifestyle and mindset
Improve your relationship with food. No deprivation or obsessive thoughts
Celebrate your progress. Track habits, weight, steps and sleep improvements
Join thousands of our members
transforming their health
Day 1
Month 9
Anneka lost 38 kg
"I feel like I'm back to my old self, and I'm showing my kids and grandkids a different example."
Anneka W.
Day 1
Month 12
Steven lost 32 kg
"Nothing else worked for me until Second Nature. My clothes have gone from 5XL to Large."
Steven W.
Day 1
Month 9
Ann lost 19 kg
"After years of struggling to lose weight and always feeling uncomfortable in my body. I have finally found something that works for me."
Ann W.
Day 1
Month 9
Anneka lost 38 kg
"I feel like I'm back to my old self, and I'm showing my kids and grandkids a different example."
Anneka W.
Day 1
Month 12
Steven lost 32 kg
"Nothing else worked for me until Second Nature. My clothes have gone from 5XL to Large."
Steven W.
Day 1
Month 9
Ann lost 19 kg
"After years of struggling to lose weight and always feeling uncomfortable in my body. I have finally found something that works for me."
Ann W.
Speak to someone
Mike Gibbs
Co-founder and COO
Book a call with our support team to talk through any questions or concerns you have. We're here to help.